Sequential recruitment and combinatorial assembling of multiprotein complexes in transcriptional activation.
In human cells, estrogenic signals induce cyclical association and dissociation of specific proteins with the DNA in order to activate transcription of estrogen-responsive genes. These oscillations can be modeled by assuming a large number of sequential reactions represented by linear kinetics with...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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2006
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| _version_ | 1797078641478205440 |
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| author | Lemaire, V Lee, C Lei, J Métivier, R Glass, L |
| author_facet | Lemaire, V Lee, C Lei, J Métivier, R Glass, L |
| author_sort | Lemaire, V |
| collection | OXFORD |
| description | In human cells, estrogenic signals induce cyclical association and dissociation of specific proteins with the DNA in order to activate transcription of estrogen-responsive genes. These oscillations can be modeled by assuming a large number of sequential reactions represented by linear kinetics with random kinetic rates. Application of the model to experimental data predicts robust binding sequences in which proteins associate with the DNA at several different phases of the oscillation. Our methods circumvent the need to derive detailed kinetic graphs, and are applicable to other oscillatory biological processes involving a large number of sequential steps. |
| first_indexed | 2024-03-07T00:34:38Z |
| format | Journal article |
| id | oxford-uuid:80fbeccd-e660-4934-a6c3-84d1b1e6dd7b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:34:38Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:80fbeccd-e660-4934-a6c3-84d1b1e6dd7b2022-03-26T21:27:08ZSequential recruitment and combinatorial assembling of multiprotein complexes in transcriptional activation.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:80fbeccd-e660-4934-a6c3-84d1b1e6dd7bEnglishSymplectic Elements at Oxford2006Lemaire, VLee, CLei, JMétivier, RGlass, LIn human cells, estrogenic signals induce cyclical association and dissociation of specific proteins with the DNA in order to activate transcription of estrogen-responsive genes. These oscillations can be modeled by assuming a large number of sequential reactions represented by linear kinetics with random kinetic rates. Application of the model to experimental data predicts robust binding sequences in which proteins associate with the DNA at several different phases of the oscillation. Our methods circumvent the need to derive detailed kinetic graphs, and are applicable to other oscillatory biological processes involving a large number of sequential steps. |
| spellingShingle | Lemaire, V Lee, C Lei, J Métivier, R Glass, L Sequential recruitment and combinatorial assembling of multiprotein complexes in transcriptional activation. |
| title | Sequential recruitment and combinatorial assembling of multiprotein complexes in transcriptional activation. |
| title_full | Sequential recruitment and combinatorial assembling of multiprotein complexes in transcriptional activation. |
| title_fullStr | Sequential recruitment and combinatorial assembling of multiprotein complexes in transcriptional activation. |
| title_full_unstemmed | Sequential recruitment and combinatorial assembling of multiprotein complexes in transcriptional activation. |
| title_short | Sequential recruitment and combinatorial assembling of multiprotein complexes in transcriptional activation. |
| title_sort | sequential recruitment and combinatorial assembling of multiprotein complexes in transcriptional activation |
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