Seroepidemiology of SARS-CoV-2 in a cohort of pregnant women and their infants in Uganda and Malawi
<p><strong>Background</p></strong> Data on SARS-CoV-2 infection in pregnancy and infancy has accumulated throughout the course of the pandemic, though evidence regarding asymptomatic SARS-CoV-2 infection and adverse birth outcomes are scarce. Limited information is available...
| Main Authors: | , , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Journal article |
| Language: | English |
| Published: |
Public Library of Science
2024
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| _version_ | 1826312974050000896 |
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| author | Hookham, L Cantrell, L Cose, S Freyne, B Gadama, L Imede, E Kawaza, K Lissauer, S Musoke, P Nankabirwa, V Sekikubo, M Sommerfelt, H Voysey, M Le Doare, K |
| author2 | periCOVID Consortium |
| author_facet | periCOVID Consortium Hookham, L Cantrell, L Cose, S Freyne, B Gadama, L Imede, E Kawaza, K Lissauer, S Musoke, P Nankabirwa, V Sekikubo, M Sommerfelt, H Voysey, M Le Doare, K |
| author_sort | Hookham, L |
| collection | OXFORD |
| description | <p><strong>Background</p></strong>
Data on SARS-CoV-2 infection in pregnancy and infancy has accumulated throughout the course of the pandemic, though evidence regarding asymptomatic SARS-CoV-2 infection and adverse birth outcomes are scarce. Limited information is available from countries in sub-Saharan Africa (SSA). The pregnant woman and infant COVID in Africa study (PeriCOVID Africa) is a South-South-North partnership involving hospitals and health centres in five countries: Malawi, Uganda, Mozambique, The Gambia, and Kenya. The study leveraged data from three ongoing prospective cohort studies: Preparing for Group B Streptococcal Vaccines (GBS PREPARE), SARS-CoV-2 infection and COVID-19 in women and their infants in Kampala and Mukono (COMAC) and Pregnancy Care Integrating Translational Science Everywhere (PRECISE). In this paper we describe the seroepidemiology of SARS-CoV-2 infection in pregnant women enrolled in sites in Uganda and Malawi, and the impact of SARS-CoV-2 infection on pregnancy and infant outcomes.
<p><strong>
Outcome</p></strong>
Seroprevalence of SARS-CoV-2 antibodies in maternal blood, reported as the proportion of seropositive women by study site and wave of COVID-19 within each country.
<p><strong>
Methods</p></strong>
The PeriCOVID study was a prospective mother-infant cohort study that recruited pregnant women at any gestation antenatally or on the day of delivery. Maternal and cord blood samples were tested for SARS-CoV-2 antibodies using Wantai and Euroimmune ELISA. In periCOVID Uganda and Malawi nose and throat swabs for SARS-Cov-2 RT-PCR were obtained.
<p><strong>
Results</p></strong>
In total, 1379 women were enrolled, giving birth to 1387 infants. Overall, 63% of pregnant women had a SARS-CoV-2 positive serology. Over subsequent waves (delta and omicron), in the absence of vaccination, seropositivity rose from 20% to over 80%. The placental transfer GMR was 1.7, indicating active placental transfer of anti-spike IgG. There was no association between SARS-CoV-2 antibody positivity and adverse pregnancy or infancy outcomes. |
| first_indexed | 2024-09-25T04:03:41Z |
| format | Journal article |
| id | oxford-uuid:80fda7c1-0bab-4f01-9658-b1727068653a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:03:41Z |
| publishDate | 2024 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | oxford-uuid:80fda7c1-0bab-4f01-9658-b1727068653a2024-05-13T16:34:25ZSeroepidemiology of SARS-CoV-2 in a cohort of pregnant women and their infants in Uganda and MalawiJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:80fda7c1-0bab-4f01-9658-b1727068653aEnglishSymplectic ElementsPublic Library of Science2024Hookham, LCantrell, LCose, SFreyne, BGadama, LImede, EKawaza, KLissauer, SMusoke, PNankabirwa, VSekikubo, MSommerfelt, HVoysey, MLe Doare, KperiCOVID Consortium<p><strong>Background</p></strong> Data on SARS-CoV-2 infection in pregnancy and infancy has accumulated throughout the course of the pandemic, though evidence regarding asymptomatic SARS-CoV-2 infection and adverse birth outcomes are scarce. Limited information is available from countries in sub-Saharan Africa (SSA). The pregnant woman and infant COVID in Africa study (PeriCOVID Africa) is a South-South-North partnership involving hospitals and health centres in five countries: Malawi, Uganda, Mozambique, The Gambia, and Kenya. The study leveraged data from three ongoing prospective cohort studies: Preparing for Group B Streptococcal Vaccines (GBS PREPARE), SARS-CoV-2 infection and COVID-19 in women and their infants in Kampala and Mukono (COMAC) and Pregnancy Care Integrating Translational Science Everywhere (PRECISE). In this paper we describe the seroepidemiology of SARS-CoV-2 infection in pregnant women enrolled in sites in Uganda and Malawi, and the impact of SARS-CoV-2 infection on pregnancy and infant outcomes. <p><strong> Outcome</p></strong> Seroprevalence of SARS-CoV-2 antibodies in maternal blood, reported as the proportion of seropositive women by study site and wave of COVID-19 within each country. <p><strong> Methods</p></strong> The PeriCOVID study was a prospective mother-infant cohort study that recruited pregnant women at any gestation antenatally or on the day of delivery. Maternal and cord blood samples were tested for SARS-CoV-2 antibodies using Wantai and Euroimmune ELISA. In periCOVID Uganda and Malawi nose and throat swabs for SARS-Cov-2 RT-PCR were obtained. <p><strong> Results</p></strong> In total, 1379 women were enrolled, giving birth to 1387 infants. Overall, 63% of pregnant women had a SARS-CoV-2 positive serology. Over subsequent waves (delta and omicron), in the absence of vaccination, seropositivity rose from 20% to over 80%. The placental transfer GMR was 1.7, indicating active placental transfer of anti-spike IgG. There was no association between SARS-CoV-2 antibody positivity and adverse pregnancy or infancy outcomes. |
| spellingShingle | Hookham, L Cantrell, L Cose, S Freyne, B Gadama, L Imede, E Kawaza, K Lissauer, S Musoke, P Nankabirwa, V Sekikubo, M Sommerfelt, H Voysey, M Le Doare, K Seroepidemiology of SARS-CoV-2 in a cohort of pregnant women and their infants in Uganda and Malawi |
| title | Seroepidemiology of SARS-CoV-2 in a cohort of pregnant women and their infants in Uganda and Malawi |
| title_full | Seroepidemiology of SARS-CoV-2 in a cohort of pregnant women and their infants in Uganda and Malawi |
| title_fullStr | Seroepidemiology of SARS-CoV-2 in a cohort of pregnant women and their infants in Uganda and Malawi |
| title_full_unstemmed | Seroepidemiology of SARS-CoV-2 in a cohort of pregnant women and their infants in Uganda and Malawi |
| title_short | Seroepidemiology of SARS-CoV-2 in a cohort of pregnant women and their infants in Uganda and Malawi |
| title_sort | seroepidemiology of sars cov 2 in a cohort of pregnant women and their infants in uganda and malawi |
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