Function, gene organization and protein structures of 11beta-hydroxysteroid dehydrogenase isoforms.
Enzymatic interconversion of active and inactive glucocorticoid hormone is important, and is carried out physiologically by 11beta-hydroxysteroid dehydrogenase (11beta-HSD) isoforms, explaining their role in cellular and toxicological processes. Two forms of the enzyme, 11beta-HSD-1 and 11beta-HSD-2...
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| Format: | Journal article |
| Language: | English |
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1997
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| _version_ | 1826281830085558272 |
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| author | Oppermann, U Persson, B Jörnvall, H |
| author_facet | Oppermann, U Persson, B Jörnvall, H |
| author_sort | Oppermann, U |
| collection | OXFORD |
| description | Enzymatic interconversion of active and inactive glucocorticoid hormone is important, and is carried out physiologically by 11beta-hydroxysteroid dehydrogenase (11beta-HSD) isoforms, explaining their role in cellular and toxicological processes. Two forms of the enzyme, 11beta-HSD-1 and 11beta-HSD-2, belonging to the protein superfamily of short-chain dehydrogenases/reductases, have been structurally and functionally characterised. Although displaying dehydrogenase and reductase activities in vitro, the dominant in vivo function of the type-1 enzyme might be to work as a reductase, thus generating active cortisol from inactive cortisone precursors. On the other hand, for adrenal glucocorticoids the type-2 enzyme seems to be exclusively a dehydrogenase and, by inactivating glucocorticoids, confers specificity to peripheral mineralocorticoid receptors. |
| first_indexed | 2024-03-07T00:34:42Z |
| format | Journal article |
| id | oxford-uuid:80ff6633-6b29-4877-bd8a-88a322dbc554 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:34:42Z |
| publishDate | 1997 |
| record_format | dspace |
| spelling | oxford-uuid:80ff6633-6b29-4877-bd8a-88a322dbc5542022-03-26T21:27:15ZFunction, gene organization and protein structures of 11beta-hydroxysteroid dehydrogenase isoforms.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:80ff6633-6b29-4877-bd8a-88a322dbc554EnglishSymplectic Elements at Oxford1997Oppermann, UPersson, BJörnvall, HEnzymatic interconversion of active and inactive glucocorticoid hormone is important, and is carried out physiologically by 11beta-hydroxysteroid dehydrogenase (11beta-HSD) isoforms, explaining their role in cellular and toxicological processes. Two forms of the enzyme, 11beta-HSD-1 and 11beta-HSD-2, belonging to the protein superfamily of short-chain dehydrogenases/reductases, have been structurally and functionally characterised. Although displaying dehydrogenase and reductase activities in vitro, the dominant in vivo function of the type-1 enzyme might be to work as a reductase, thus generating active cortisol from inactive cortisone precursors. On the other hand, for adrenal glucocorticoids the type-2 enzyme seems to be exclusively a dehydrogenase and, by inactivating glucocorticoids, confers specificity to peripheral mineralocorticoid receptors. |
| spellingShingle | Oppermann, U Persson, B Jörnvall, H Function, gene organization and protein structures of 11beta-hydroxysteroid dehydrogenase isoforms. |
| title | Function, gene organization and protein structures of 11beta-hydroxysteroid dehydrogenase isoforms. |
| title_full | Function, gene organization and protein structures of 11beta-hydroxysteroid dehydrogenase isoforms. |
| title_fullStr | Function, gene organization and protein structures of 11beta-hydroxysteroid dehydrogenase isoforms. |
| title_full_unstemmed | Function, gene organization and protein structures of 11beta-hydroxysteroid dehydrogenase isoforms. |
| title_short | Function, gene organization and protein structures of 11beta-hydroxysteroid dehydrogenase isoforms. |
| title_sort | function gene organization and protein structures of 11beta hydroxysteroid dehydrogenase isoforms |
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