Cardiac regeneration following myocardial infarction: the need for regeneration and a review of cardiac stromal cell populations used for transplantation
Myocardial infarction is a leading cause of death globally due to the inability of the adult human heart to regenerate after injury. Cell therapy using cardiac-derived progenitor populations emerged about two decades ago with the aim of replacing cells lost after ischaemic injury. Despite early prom...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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Portland Press
2022
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| _version_ | 1797106920386985984 |
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| author | Alonaizan, R Carr, C |
| author_facet | Alonaizan, R Carr, C |
| author_sort | Alonaizan, R |
| collection | OXFORD |
| description | Myocardial infarction is a leading cause of death globally due to the inability of the adult human heart to regenerate after injury. Cell therapy using cardiac-derived progenitor populations emerged about two decades ago with the aim of replacing cells lost after ischaemic injury. Despite early promise from rodent studies, administration of these populations has not translated to the clinic. We will discuss the need for cardiac regeneration and review the debate surrounding how cardiac progenitor populations exert a therapeutic effect following transplantation into the heart, including their ability to form de novo cardiomyocytes and the release of paracrine factors. We will also discuss limitations hindering the cell therapy field, which include the challenges of performing cell-based clinical trials and the low retention of administered cells, and how future research may overcome them. |
| first_indexed | 2024-03-07T07:07:52Z |
| format | Journal article |
| id | oxford-uuid:8100b410-d7f6-4b5d-9faa-1b9e1008aaf0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:07:52Z |
| publishDate | 2022 |
| publisher | Portland Press |
| record_format | dspace |
| spelling | oxford-uuid:8100b410-d7f6-4b5d-9faa-1b9e1008aaf02022-05-24T13:10:32ZCardiac regeneration following myocardial infarction: the need for regeneration and a review of cardiac stromal cell populations used for transplantationJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8100b410-d7f6-4b5d-9faa-1b9e1008aaf0EnglishSymplectic ElementsPortland Press2022Alonaizan, RCarr, CMyocardial infarction is a leading cause of death globally due to the inability of the adult human heart to regenerate after injury. Cell therapy using cardiac-derived progenitor populations emerged about two decades ago with the aim of replacing cells lost after ischaemic injury. Despite early promise from rodent studies, administration of these populations has not translated to the clinic. We will discuss the need for cardiac regeneration and review the debate surrounding how cardiac progenitor populations exert a therapeutic effect following transplantation into the heart, including their ability to form de novo cardiomyocytes and the release of paracrine factors. We will also discuss limitations hindering the cell therapy field, which include the challenges of performing cell-based clinical trials and the low retention of administered cells, and how future research may overcome them. |
| spellingShingle | Alonaizan, R Carr, C Cardiac regeneration following myocardial infarction: the need for regeneration and a review of cardiac stromal cell populations used for transplantation |
| title | Cardiac regeneration following myocardial infarction: the need for regeneration and a review of cardiac stromal cell populations used for transplantation |
| title_full | Cardiac regeneration following myocardial infarction: the need for regeneration and a review of cardiac stromal cell populations used for transplantation |
| title_fullStr | Cardiac regeneration following myocardial infarction: the need for regeneration and a review of cardiac stromal cell populations used for transplantation |
| title_full_unstemmed | Cardiac regeneration following myocardial infarction: the need for regeneration and a review of cardiac stromal cell populations used for transplantation |
| title_short | Cardiac regeneration following myocardial infarction: the need for regeneration and a review of cardiac stromal cell populations used for transplantation |
| title_sort | cardiac regeneration following myocardial infarction the need for regeneration and a review of cardiac stromal cell populations used for transplantation |
| work_keys_str_mv | AT alonaizanr cardiacregenerationfollowingmyocardialinfarctiontheneedforregenerationandareviewofcardiacstromalcellpopulationsusedfortransplantation AT carrc cardiacregenerationfollowingmyocardialinfarctiontheneedforregenerationandareviewofcardiacstromalcellpopulationsusedfortransplantation |