A prodrug system for hydroxylamines based on esterase catalysis.
The synthesis and reactivity of hydroxy hydroxamates as models for a prodrug form of hydroxylamine are described. Gamma-hydroxy hydroxamates were found to enable hydroxylamine release via lactonisation. Hydroxamates were found to undergo esterase catalysed hydrolysis.
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2005
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