P-selectin dependent targeting to inflamed endothelium of recombinant P-selectin glycoprotein ligand-1 immunoglobulin chimera-coated poly[N-(2-hydroxypropyl) methacrylamide]-DNA polyplexes in vivo visualised by intravital microscopy.
BACKGROUND: Developing vectors that target specifically to disease sites after systemic injection is an important goal in gene therapy research. METHODS: We prepared fluorescent DNA polyplexes (< or =150 nm in diameter) comprising plasmid DNA condensed with poly(L-lysine) and coated with a mu...
Main Authors: | Newman, C, Crosdale, D, Fisher, K, Briggs, S, Norman, K, Seymour, L, Hellewell, P |
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Format: | Journal article |
Language: | English |
Published: |
2009
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