| Summary: | <p><strong>BACKGROUND:</strong> Parkinson's disease (PD) etiology is not well understood. Reported inverse associations with smoking and coffee consumption prompted the investigation of alcohol consumption as a risk factor, for which evidence is inconclusive.</p>
<p><strong>OBJECTIVE:</strong> To assess the associations between alcohol consumption and PD risk.</p>
<p><strong>METHODS:</strong> Within NeuroEPIC4PD, a prospective European population-based cohort, 694 incident PD cases were ascertained from 209,998 PD-free participants. Average alcohol consumption at different time points was self-reported at recruitment. Cox regression hazard ratios were estimated for alcohol consumption and PD occurrence.</p>
<p><strong>RESULTS:</strong> No associations between baseline or lifetime total alcohol consumption and PD risk were observed. Men with moderate lifetime consumption (5-29.9 g/day) were at ~50% higher risk compared with light consumption (0.1-4.9 g/day), but no linear exposure-response trend was observed. Analyses by beverage type also revealed no associations with PD.</p>
<p><strong>CONCLUSION:</strong> Our data reinforce previous findings from prospective studies showing no association between alcohol consumption and PD risk.</p>
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