Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a further 34,412 cases and 59,925 controls, we identified 12 new T2D association signals with combined...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2010
|
| _version_ | 1797078715889352704 |
|---|---|
| author | Voight, B Scott, L Steinthorsdottir, V Morris, A Dina, C Welch, R Zeggini, E Huth, C Aulchenko, Y Thorleifsson, G McCulloch, L Ferreira, T Grallert, H Amin, N Wu, G Willer, C Raychaudhuri, S McCarroll, SA Langenberg, C Hofmann, O Dupuis, J Qi, L Segre, A van Hoek, M Navarro, P |
| author_facet | Voight, B Scott, L Steinthorsdottir, V Morris, A Dina, C Welch, R Zeggini, E Huth, C Aulchenko, Y Thorleifsson, G McCulloch, L Ferreira, T Grallert, H Amin, N Wu, G Willer, C Raychaudhuri, S McCarroll, SA Langenberg, C Hofmann, O Dupuis, J Qi, L Segre, A van Hoek, M Navarro, P |
| author_sort | Voight, B |
| collection | OXFORD |
| description | By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a further 34,412 cases and 59,925 controls, we identified 12 new T2D association signals with combined P 5 × 10 8. These include a second independent signal at the KCNQ1 locus; the first report, to our knowledge, of an X-chromosomal association (near DUSP9); and a further instance of overlap between loci implicated in monogenic and multifactorial forms of diabetes (at HNF1A). The identified loci affect both beta-cell function and insulin action, and, overall, T2D association signals show evidence of enrichment for genes involved in cell cycle regulation. We also show that a high proportion of T2D susceptibility loci harbor independent association signals influencing apparently unrelated complex traits. © 2010 Nature America, Inc. All rights reserved. |
| first_indexed | 2024-03-07T00:35:41Z |
| format | Journal article |
| id | oxford-uuid:81510c32-c108-482e-988d-51b5b19f70b4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:35:41Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:81510c32-c108-482e-988d-51b5b19f70b42022-03-26T21:29:38ZTwelve type 2 diabetes susceptibility loci identified through large-scale association analysisJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:81510c32-c108-482e-988d-51b5b19f70b4EnglishSymplectic Elements at Oxford2010Voight, BScott, LSteinthorsdottir, VMorris, ADina, CWelch, RZeggini, EHuth, CAulchenko, YThorleifsson, GMcCulloch, LFerreira, TGrallert, HAmin, NWu, GWiller, CRaychaudhuri, SMcCarroll, SALangenberg, CHofmann, ODupuis, JQi, LSegre, Avan Hoek, MNavarro, PBy combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a further 34,412 cases and 59,925 controls, we identified 12 new T2D association signals with combined P 5 × 10 8. These include a second independent signal at the KCNQ1 locus; the first report, to our knowledge, of an X-chromosomal association (near DUSP9); and a further instance of overlap between loci implicated in monogenic and multifactorial forms of diabetes (at HNF1A). The identified loci affect both beta-cell function and insulin action, and, overall, T2D association signals show evidence of enrichment for genes involved in cell cycle regulation. We also show that a high proportion of T2D susceptibility loci harbor independent association signals influencing apparently unrelated complex traits. © 2010 Nature America, Inc. All rights reserved. |
| spellingShingle | Voight, B Scott, L Steinthorsdottir, V Morris, A Dina, C Welch, R Zeggini, E Huth, C Aulchenko, Y Thorleifsson, G McCulloch, L Ferreira, T Grallert, H Amin, N Wu, G Willer, C Raychaudhuri, S McCarroll, SA Langenberg, C Hofmann, O Dupuis, J Qi, L Segre, A van Hoek, M Navarro, P Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis |
| title | Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis |
| title_full | Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis |
| title_fullStr | Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis |
| title_full_unstemmed | Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis |
| title_short | Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis |
| title_sort | twelve type 2 diabetes susceptibility loci identified through large scale association analysis |
| work_keys_str_mv | AT voightb twelvetype2diabetessusceptibilitylociidentifiedthroughlargescaleassociationanalysis AT scottl twelvetype2diabetessusceptibilitylociidentifiedthroughlargescaleassociationanalysis AT steinthorsdottirv twelvetype2diabetessusceptibilitylociidentifiedthroughlargescaleassociationanalysis AT morrisa twelvetype2diabetessusceptibilitylociidentifiedthroughlargescaleassociationanalysis AT dinac twelvetype2diabetessusceptibilitylociidentifiedthroughlargescaleassociationanalysis AT welchr twelvetype2diabetessusceptibilitylociidentifiedthroughlargescaleassociationanalysis AT zegginie twelvetype2diabetessusceptibilitylociidentifiedthroughlargescaleassociationanalysis AT huthc twelvetype2diabetessusceptibilitylociidentifiedthroughlargescaleassociationanalysis AT aulchenkoy twelvetype2diabetessusceptibilitylociidentifiedthroughlargescaleassociationanalysis AT thorleifssong twelvetype2diabetessusceptibilitylociidentifiedthroughlargescaleassociationanalysis AT mccullochl twelvetype2diabetessusceptibilitylociidentifiedthroughlargescaleassociationanalysis AT ferreirat twelvetype2diabetessusceptibilitylociidentifiedthroughlargescaleassociationanalysis AT grallerth twelvetype2diabetessusceptibilitylociidentifiedthroughlargescaleassociationanalysis AT aminn twelvetype2diabetessusceptibilitylociidentifiedthroughlargescaleassociationanalysis AT wug twelvetype2diabetessusceptibilitylociidentifiedthroughlargescaleassociationanalysis AT willerc twelvetype2diabetessusceptibilitylociidentifiedthroughlargescaleassociationanalysis AT raychaudhuris twelvetype2diabetessusceptibilitylociidentifiedthroughlargescaleassociationanalysis AT mccarrollsa twelvetype2diabetessusceptibilitylociidentifiedthroughlargescaleassociationanalysis AT langenbergc twelvetype2diabetessusceptibilitylociidentifiedthroughlargescaleassociationanalysis AT hofmanno twelvetype2diabetessusceptibilitylociidentifiedthroughlargescaleassociationanalysis AT dupuisj twelvetype2diabetessusceptibilitylociidentifiedthroughlargescaleassociationanalysis AT qil twelvetype2diabetessusceptibilitylociidentifiedthroughlargescaleassociationanalysis AT segrea twelvetype2diabetessusceptibilitylociidentifiedthroughlargescaleassociationanalysis AT vanhoekm twelvetype2diabetessusceptibilitylociidentifiedthroughlargescaleassociationanalysis AT navarrop twelvetype2diabetessusceptibilitylociidentifiedthroughlargescaleassociationanalysis |