Iron deficiency is associated with reduced levels of Plasmodium falciparum-specific antibodies in African children
<p><strong>Background:</strong> Iron deficiency (ID) and malaria are common causes of ill-health and disability among children living in sub-Saharan Africa. Although iron is critical for the acquisition of humoral immunity, little is known about the effects of ID on antibody respon...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Oxford University Press
2020
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| _version_ | 1797078726428590080 |
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| author | Bundi, CK Nalwoga, A Lubyayi, L Muriuki, J Mogire, R Opi, H Mentzer, AJ Mugyenyi, CK Mwacharo, J Webb, EL Bejon, P Williams, TN Gikunju, J Beeson, J Elliott, A Ndungu, FM Atkinson, SH |
| author_facet | Bundi, CK Nalwoga, A Lubyayi, L Muriuki, J Mogire, R Opi, H Mentzer, AJ Mugyenyi, CK Mwacharo, J Webb, EL Bejon, P Williams, TN Gikunju, J Beeson, J Elliott, A Ndungu, FM Atkinson, SH |
| author_sort | Bundi, CK |
| collection | OXFORD |
| description | <p><strong>Background:</strong> Iron deficiency (ID) and malaria are common causes of ill-health and disability among children living in sub-Saharan Africa. Although iron is critical for the acquisition of humoral immunity, little is known about the effects of ID on antibody responses to Plasmodium falciparum malaria.</p>
<p><strong>Methods:</strong> The study included 1,794 Kenyan and Ugandan children aged 0-7 years. We measured biomarkers of iron and inflammation, and antibodies to P falciparum antigens including apical merozoite antigen 1 (anti-AMA-1) and merozoite surface antigen 1 (anti-56 MSP-1) in cross-sectional and longitudinal studies.</p>
<p><strong>Results:</strong> The overall prevalence of ID was 31%. ID was associated with lower anti-AMA-1 and anti-MSP-1 antibody levels in pooled analyses adjusted for age, gender, study site, inflammation and P falciparum parasitemia (adjusted mean difference on a log-transformed scale (β) -0.46; 95 CI -0.66, -0.25 P <0.0001; β -0.33; 95 CI -0.50, -0.16 P <0.0001, respectively). Additional covariates for malaria exposure index, previous malaria episodes, and time since last malaria episode, were available for individual cohorts. Meta-analysis was used to allow for these adjustments giving β -0.34; -0.52, -0.16 for anti-AMA-1 antibodies and β -0.26; -0.41, -0.11 for anti-MSP-1 antibodies. Low transferrin saturation was similarly associated with reduced anti-AMA1 antibody levels. Lower AMA-1 and MSP-1 specific antibody levels persisted over time in iron-deficient children.</p>
<p><strong>Conclusions:</strong> Reduced levels of P. falciparum-specific antibodies in iron-deficient children might reflect impaired acquisition of immunity to malaria and/or reduced malaria exposure. Strategies to prevent and treat ID may influence antibody responses to malaria for children living in sub-Saharan Africa.</p> |
| first_indexed | 2024-03-07T00:35:52Z |
| format | Journal article |
| id | oxford-uuid:8162e4f4-968b-4f12-8c99-70cf9b9fb884 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:35:52Z |
| publishDate | 2020 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:8162e4f4-968b-4f12-8c99-70cf9b9fb8842022-03-26T21:29:59ZIron deficiency is associated with reduced levels of Plasmodium falciparum-specific antibodies in African childrenJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8162e4f4-968b-4f12-8c99-70cf9b9fb884EnglishSymplectic ElementsOxford University Press2020Bundi, CKNalwoga, ALubyayi, LMuriuki, JMogire, ROpi, HMentzer, AJMugyenyi, CKMwacharo, JWebb, ELBejon, PWilliams, TNGikunju, JBeeson, JElliott, ANdungu, FMAtkinson, SH<p><strong>Background:</strong> Iron deficiency (ID) and malaria are common causes of ill-health and disability among children living in sub-Saharan Africa. Although iron is critical for the acquisition of humoral immunity, little is known about the effects of ID on antibody responses to Plasmodium falciparum malaria.</p> <p><strong>Methods:</strong> The study included 1,794 Kenyan and Ugandan children aged 0-7 years. We measured biomarkers of iron and inflammation, and antibodies to P falciparum antigens including apical merozoite antigen 1 (anti-AMA-1) and merozoite surface antigen 1 (anti-56 MSP-1) in cross-sectional and longitudinal studies.</p> <p><strong>Results:</strong> The overall prevalence of ID was 31%. ID was associated with lower anti-AMA-1 and anti-MSP-1 antibody levels in pooled analyses adjusted for age, gender, study site, inflammation and P falciparum parasitemia (adjusted mean difference on a log-transformed scale (β) -0.46; 95 CI -0.66, -0.25 P <0.0001; β -0.33; 95 CI -0.50, -0.16 P <0.0001, respectively). Additional covariates for malaria exposure index, previous malaria episodes, and time since last malaria episode, were available for individual cohorts. Meta-analysis was used to allow for these adjustments giving β -0.34; -0.52, -0.16 for anti-AMA-1 antibodies and β -0.26; -0.41, -0.11 for anti-MSP-1 antibodies. Low transferrin saturation was similarly associated with reduced anti-AMA1 antibody levels. Lower AMA-1 and MSP-1 specific antibody levels persisted over time in iron-deficient children.</p> <p><strong>Conclusions:</strong> Reduced levels of P. falciparum-specific antibodies in iron-deficient children might reflect impaired acquisition of immunity to malaria and/or reduced malaria exposure. Strategies to prevent and treat ID may influence antibody responses to malaria for children living in sub-Saharan Africa.</p> |
| spellingShingle | Bundi, CK Nalwoga, A Lubyayi, L Muriuki, J Mogire, R Opi, H Mentzer, AJ Mugyenyi, CK Mwacharo, J Webb, EL Bejon, P Williams, TN Gikunju, J Beeson, J Elliott, A Ndungu, FM Atkinson, SH Iron deficiency is associated with reduced levels of Plasmodium falciparum-specific antibodies in African children |
| title | Iron deficiency is associated with reduced levels of Plasmodium falciparum-specific antibodies in African children |
| title_full | Iron deficiency is associated with reduced levels of Plasmodium falciparum-specific antibodies in African children |
| title_fullStr | Iron deficiency is associated with reduced levels of Plasmodium falciparum-specific antibodies in African children |
| title_full_unstemmed | Iron deficiency is associated with reduced levels of Plasmodium falciparum-specific antibodies in African children |
| title_short | Iron deficiency is associated with reduced levels of Plasmodium falciparum-specific antibodies in African children |
| title_sort | iron deficiency is associated with reduced levels of plasmodium falciparum specific antibodies in african children |
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