Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl.

Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl.

The mechanism by which Wnt receptors transduce signals to activate downstream beta-catenin-mediated target gene transcription remains incompletely understood but involves Frizzled (Fz) receptor-mediated plasma membrane recruitment and activation of the cytoplasmic effector Dishevelled (Dvl). Here, w...

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Bibliographic Details
Main Authors:	Tauriello, D, Haegebarth, A, Kuper, I, Edelmann, M, Henraat, M, Canninga-van Dijk, MR, Kessler, B, Clevers, H, Maurice, M
Format:	Journal article
Language:	English
Published:	2010

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