Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study.
BACKGROUND: Dietary fibre is thought to protect against colorectal cancer but this view has been challenged by recent prospective and intervention studies that showed no protective effect. METHODS: We prospectively examined the association between dietary fibre intake and incidence of colorectal can...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2003
|
| _version_ | 1826281930909286400 |
|---|---|
| author | Bingham, SA Day, N Luben, R Ferrari, P Slimani, N Norat, T Clavel-Chapelon, F Kesse, E Nieters, A Boeing, H Tjønneland, A Overvad, K Martinez, C Dorronsoro, M Gonzalez, C Key, T Trichopoulou, A Naska, A Vineis, P Tumino, R Krogh, V Bueno-de-Mesquita, H Peeters, P Berglund, G Hallmans, G |
| author_facet | Bingham, SA Day, N Luben, R Ferrari, P Slimani, N Norat, T Clavel-Chapelon, F Kesse, E Nieters, A Boeing, H Tjønneland, A Overvad, K Martinez, C Dorronsoro, M Gonzalez, C Key, T Trichopoulou, A Naska, A Vineis, P Tumino, R Krogh, V Bueno-de-Mesquita, H Peeters, P Berglund, G Hallmans, G |
| author_sort | Bingham, SA |
| collection | OXFORD |
| description | BACKGROUND: Dietary fibre is thought to protect against colorectal cancer but this view has been challenged by recent prospective and intervention studies that showed no protective effect. METHODS: We prospectively examined the association between dietary fibre intake and incidence of colorectal cancer in 519978 individuals aged 25-70 years taking part in the EPIC study, recruited from ten European countries. Participants completed a dietary questionnaire in 1992-98 and were followed up for cancer incidence. Relative risk estimates were obtained from fibre intake, categorised by sex-specific, cohort-wide quintiles, and from linear models relating the hazard ratio to fibre intake expressed as a continuous variable. FINDINGS: Follow-up consisted of 1939011 person-years, and data for 1065 reported cases of colorectal cancer were included in the analysis. Dietary fibre in foods was inversely related to incidence of large bowel cancer (adjusted relative risk 0.75 [95% CI 0.59-0.95] for the highest versus lowest quintile of intake), the protective effect being greatest for the left side of the colon, and least for the rectum. After calibration with more detailed dietary data, the adjusted relative risk for the highest versus lowest quintile of fibre from food intake was 0.58 (0.41-0.85). No food source of fibre was significantly more protective than others, and non-food supplement sources of fibre were not investigated. INTERPRETATION: In populations with low average intake of dietary fibre, an approximate doubling of total fibre intake from foods could reduce the risk of colorectal cancer by 40%. |
| first_indexed | 2024-03-07T00:36:13Z |
| format | Journal article |
| id | oxford-uuid:818075dc-9cf7-409c-83c8-70084217c7d1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:36:13Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:818075dc-9cf7-409c-83c8-70084217c7d12022-03-26T21:30:46ZDietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:818075dc-9cf7-409c-83c8-70084217c7d1EnglishSymplectic Elements at Oxford2003Bingham, SADay, NLuben, RFerrari, PSlimani, NNorat, TClavel-Chapelon, FKesse, ENieters, ABoeing, HTjønneland, AOvervad, KMartinez, CDorronsoro, MGonzalez, CKey, TTrichopoulou, ANaska, AVineis, PTumino, RKrogh, VBueno-de-Mesquita, HPeeters, PBerglund, GHallmans, GBACKGROUND: Dietary fibre is thought to protect against colorectal cancer but this view has been challenged by recent prospective and intervention studies that showed no protective effect. METHODS: We prospectively examined the association between dietary fibre intake and incidence of colorectal cancer in 519978 individuals aged 25-70 years taking part in the EPIC study, recruited from ten European countries. Participants completed a dietary questionnaire in 1992-98 and were followed up for cancer incidence. Relative risk estimates were obtained from fibre intake, categorised by sex-specific, cohort-wide quintiles, and from linear models relating the hazard ratio to fibre intake expressed as a continuous variable. FINDINGS: Follow-up consisted of 1939011 person-years, and data for 1065 reported cases of colorectal cancer were included in the analysis. Dietary fibre in foods was inversely related to incidence of large bowel cancer (adjusted relative risk 0.75 [95% CI 0.59-0.95] for the highest versus lowest quintile of intake), the protective effect being greatest for the left side of the colon, and least for the rectum. After calibration with more detailed dietary data, the adjusted relative risk for the highest versus lowest quintile of fibre from food intake was 0.58 (0.41-0.85). No food source of fibre was significantly more protective than others, and non-food supplement sources of fibre were not investigated. INTERPRETATION: In populations with low average intake of dietary fibre, an approximate doubling of total fibre intake from foods could reduce the risk of colorectal cancer by 40%. |
| spellingShingle | Bingham, SA Day, N Luben, R Ferrari, P Slimani, N Norat, T Clavel-Chapelon, F Kesse, E Nieters, A Boeing, H Tjønneland, A Overvad, K Martinez, C Dorronsoro, M Gonzalez, C Key, T Trichopoulou, A Naska, A Vineis, P Tumino, R Krogh, V Bueno-de-Mesquita, H Peeters, P Berglund, G Hallmans, G Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study. |
| title | Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study. |
| title_full | Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study. |
| title_fullStr | Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study. |
| title_full_unstemmed | Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study. |
| title_short | Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study. |
| title_sort | dietary fibre in food and protection against colorectal cancer in the european prospective investigation into cancer and nutrition epic an observational study |
| work_keys_str_mv | AT binghamsa dietaryfibreinfoodandprotectionagainstcolorectalcancerintheeuropeanprospectiveinvestigationintocancerandnutritionepicanobservationalstudy AT dayn dietaryfibreinfoodandprotectionagainstcolorectalcancerintheeuropeanprospectiveinvestigationintocancerandnutritionepicanobservationalstudy AT lubenr dietaryfibreinfoodandprotectionagainstcolorectalcancerintheeuropeanprospectiveinvestigationintocancerandnutritionepicanobservationalstudy AT ferrarip dietaryfibreinfoodandprotectionagainstcolorectalcancerintheeuropeanprospectiveinvestigationintocancerandnutritionepicanobservationalstudy AT slimanin dietaryfibreinfoodandprotectionagainstcolorectalcancerintheeuropeanprospectiveinvestigationintocancerandnutritionepicanobservationalstudy AT noratt dietaryfibreinfoodandprotectionagainstcolorectalcancerintheeuropeanprospectiveinvestigationintocancerandnutritionepicanobservationalstudy AT clavelchapelonf dietaryfibreinfoodandprotectionagainstcolorectalcancerintheeuropeanprospectiveinvestigationintocancerandnutritionepicanobservationalstudy AT kessee dietaryfibreinfoodandprotectionagainstcolorectalcancerintheeuropeanprospectiveinvestigationintocancerandnutritionepicanobservationalstudy AT nietersa dietaryfibreinfoodandprotectionagainstcolorectalcancerintheeuropeanprospectiveinvestigationintocancerandnutritionepicanobservationalstudy AT boeingh dietaryfibreinfoodandprotectionagainstcolorectalcancerintheeuropeanprospectiveinvestigationintocancerandnutritionepicanobservationalstudy AT tjønnelanda dietaryfibreinfoodandprotectionagainstcolorectalcancerintheeuropeanprospectiveinvestigationintocancerandnutritionepicanobservationalstudy AT overvadk dietaryfibreinfoodandprotectionagainstcolorectalcancerintheeuropeanprospectiveinvestigationintocancerandnutritionepicanobservationalstudy AT martinezc dietaryfibreinfoodandprotectionagainstcolorectalcancerintheeuropeanprospectiveinvestigationintocancerandnutritionepicanobservationalstudy AT dorronsorom dietaryfibreinfoodandprotectionagainstcolorectalcancerintheeuropeanprospectiveinvestigationintocancerandnutritionepicanobservationalstudy AT gonzalezc dietaryfibreinfoodandprotectionagainstcolorectalcancerintheeuropeanprospectiveinvestigationintocancerandnutritionepicanobservationalstudy AT keyt dietaryfibreinfoodandprotectionagainstcolorectalcancerintheeuropeanprospectiveinvestigationintocancerandnutritionepicanobservationalstudy AT trichopouloua dietaryfibreinfoodandprotectionagainstcolorectalcancerintheeuropeanprospectiveinvestigationintocancerandnutritionepicanobservationalstudy AT naskaa dietaryfibreinfoodandprotectionagainstcolorectalcancerintheeuropeanprospectiveinvestigationintocancerandnutritionepicanobservationalstudy AT vineisp dietaryfibreinfoodandprotectionagainstcolorectalcancerintheeuropeanprospectiveinvestigationintocancerandnutritionepicanobservationalstudy AT tuminor dietaryfibreinfoodandprotectionagainstcolorectalcancerintheeuropeanprospectiveinvestigationintocancerandnutritionepicanobservationalstudy AT kroghv dietaryfibreinfoodandprotectionagainstcolorectalcancerintheeuropeanprospectiveinvestigationintocancerandnutritionepicanobservationalstudy AT buenodemesquitah dietaryfibreinfoodandprotectionagainstcolorectalcancerintheeuropeanprospectiveinvestigationintocancerandnutritionepicanobservationalstudy AT peetersp dietaryfibreinfoodandprotectionagainstcolorectalcancerintheeuropeanprospectiveinvestigationintocancerandnutritionepicanobservationalstudy AT berglundg dietaryfibreinfoodandprotectionagainstcolorectalcancerintheeuropeanprospectiveinvestigationintocancerandnutritionepicanobservationalstudy AT hallmansg dietaryfibreinfoodandprotectionagainstcolorectalcancerintheeuropeanprospectiveinvestigationintocancerandnutritionepicanobservationalstudy |