The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses.
The innate immune system responds to infection and tissue damage by activating cytosolic sensory complexes called 'inflammasomes'. Cytosolic DNA is sensed by AIM2-like receptors (ALRs) during bacterial and viral infections and in autoimmune diseases. Subsequently, recruitment of the inflam...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2014
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| _version_ | 1797078757067980800 |
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| author | Khare, S Ratsimandresy, R de Almeida, L Cuda, C Rellick, S Misharin, A Wallin, M Gangopadhyay, A Forte, E Gottwein, E Perlman, H Reed, J Greaves, D Dorfleutner, A Stehlik, C |
| author_facet | Khare, S Ratsimandresy, R de Almeida, L Cuda, C Rellick, S Misharin, A Wallin, M Gangopadhyay, A Forte, E Gottwein, E Perlman, H Reed, J Greaves, D Dorfleutner, A Stehlik, C |
| author_sort | Khare, S |
| collection | OXFORD |
| description | The innate immune system responds to infection and tissue damage by activating cytosolic sensory complexes called 'inflammasomes'. Cytosolic DNA is sensed by AIM2-like receptors (ALRs) during bacterial and viral infections and in autoimmune diseases. Subsequently, recruitment of the inflammasome adaptor ASC links ALRs to the activation of caspase-1. A controlled immune response is crucial for maintaining homeostasis, but the regulation of ALR inflammasomes is poorly understood. Here we identified the PYRIN domain (PYD)-only protein POP3, which competes with ASC for recruitment to ALRs, as an inhibitor of DNA virus-induced activation of ALR inflammasomes in vivo. Data obtained with a mouse model with macrophage-specific POP3 expression emphasize the importance of the regulation of ALR inflammasomes in monocytes and macrophages. |
| first_indexed | 2024-03-07T00:36:19Z |
| format | Journal article |
| id | oxford-uuid:81894064-ca9c-4be3-9783-a3cb667a0a7b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:36:19Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | oxford-uuid:81894064-ca9c-4be3-9783-a3cb667a0a7b2022-03-26T21:30:54ZThe PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:81894064-ca9c-4be3-9783-a3cb667a0a7bEnglishSymplectic Elements at Oxford2014Khare, SRatsimandresy, Rde Almeida, LCuda, CRellick, SMisharin, AWallin, MGangopadhyay, AForte, EGottwein, EPerlman, HReed, JGreaves, DDorfleutner, AStehlik, CThe innate immune system responds to infection and tissue damage by activating cytosolic sensory complexes called 'inflammasomes'. Cytosolic DNA is sensed by AIM2-like receptors (ALRs) during bacterial and viral infections and in autoimmune diseases. Subsequently, recruitment of the inflammasome adaptor ASC links ALRs to the activation of caspase-1. A controlled immune response is crucial for maintaining homeostasis, but the regulation of ALR inflammasomes is poorly understood. Here we identified the PYRIN domain (PYD)-only protein POP3, which competes with ASC for recruitment to ALRs, as an inhibitor of DNA virus-induced activation of ALR inflammasomes in vivo. Data obtained with a mouse model with macrophage-specific POP3 expression emphasize the importance of the regulation of ALR inflammasomes in monocytes and macrophages. |
| spellingShingle | Khare, S Ratsimandresy, R de Almeida, L Cuda, C Rellick, S Misharin, A Wallin, M Gangopadhyay, A Forte, E Gottwein, E Perlman, H Reed, J Greaves, D Dorfleutner, A Stehlik, C The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses. |
| title | The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses. |
| title_full | The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses. |
| title_fullStr | The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses. |
| title_full_unstemmed | The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses. |
| title_short | The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses. |
| title_sort | pyrin domain only protein pop3 inhibits alr inflammasomes and regulates responses to infection with dna viruses |
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