The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses.

The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses.

The innate immune system responds to infection and tissue damage by activating cytosolic sensory complexes called 'inflammasomes'. Cytosolic DNA is sensed by AIM2-like receptors (ALRs) during bacterial and viral infections and in autoimmune diseases. Subsequently, recruitment of the inflam...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Khare, S, Ratsimandresy, R, de Almeida, L, Cuda, C, Rellick, S, Misharin, A, Wallin, M, Gangopadhyay, A, Forte, E, Gottwein, E, Perlman, H, Reed, J, Greaves, D, Dorfleutner, A, Stehlik, C
Format: Journal article
Sprache:English
Veröffentlicht: 2014

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