Identification of common variants associated with human hippocampal and intracranial volumes.
Identifying genetic variants influencing human brain structures may reveal new biological mechanisms underlying cognition and neuropsychiatric illness. The volume of the hippocampus is a biomarker of incipient Alzheimer's disease and is reduced in schizophrenia, major depression and mesial temp...
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| Aineistotyyppi: | Journal article |
| Kieli: | English |
| Julkaistu: |
Nature Publishing Group
2012
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| _version_ | 1826281950841667584 |
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| author | Stein, J Medland, SE Vasquez, A Hibar, D Senstad, R Winkler, A Toro, R Appel, K Bartecek, R Bergmann, Ø Bernard, M Brown, A Cannon, D Chakravarty, M Christoforou, A Domin, M Grimm, O Hollinshead, M Holmes, A Homuth, G Hottenga, J Langan, C Lopez, L Hansell, N Hwang, K Kim, S Laje, G Lee, P Liu, X Loth, E Lourdusamy, A Mattingsdal, M Mohnke, S Maniega, S Nho, K Nugent, A O'Brien, C Papmeyer, M Pütz, B Ramasamy, A Rasmussen, J Rijpkema, M Risacher, S Roddey, J Rose, E Ryten, M Shen, L Sprooten, E Strengman, E Teumer, A Trabzuni, D Turner, J van Eijk, K van Erp, T van Tol, M Wittfeld, K Wolf, C Woudstra, S Aleman, A Alhusaini, S Almasy, L Binder, E Brohawn, D Cantor, R Carless, M Corvin, A Czisch, M Curran, J Davies, G Almeida, d Delanty, N Depondt, C Duggirala, R Dyer, T Erk, S Fagerness, J Fox, P Freimer, N Gill, M Göring, H Hagler, D Hoehn, D Holsboer, F Hoogman, M Hosten, N Jahanshad, N Johnson, M Kasperaviciute, D Kent, J Kochunov, P Lancaster, J Lawrie, S Liewald, D Mandl, R Matarin, M Mattheisen, M Meisenzahl, E Melle, I Moses, E Mühleisen, T Nauck, M Nöthen, M Olvera, R Pandolfo, M Pike, G Puls, R Reinvang, I Rentería, M Rietschel, M Roffman, J Royle, N Rujescu, D Savitz, J Schnack, H Schnell, K Seiferth, N Smith, C Steen, V Hernández, V Van den Heuvel, M van der Wee, N Van Haren, N Veltman, J Völzke, H Walker, R Westlye, LT Whelan, C Agartz, I Boomsma, D Cavalleri, G Dale, A Djurovic, S Drevets, W Hagoort, P Hall, J Heinz, A Jack, C Foroud, T Le Hellard, S Macciardi, F Montgomery, G Poline, J Porteous, D Sisodiya, S Starr, J Sussmann, J Toga, A Veltman, D Walter, H Weiner, M Bis, J Ikram, M Smith, A Gudnason, V Tzourio, C Vernooij, M Launer, L DeCarli, C Seshadri, S Andreassen, O Apostolova, L Bastin, M Blangero, J Brunner, H Buckner, R Cichon, S Coppola, G de Zubicaray, G Deary, I Donohoe, G de Geus, E Espeseth, T Fernández, G Glahn, D Grabe, H Hardy, J Hulshoff Pol, H Jenkinson, M Kahn, R McDonald, C McIntosh, A McMahon, F McMahon, K Meyer-Lindenberg, A Morris, D Müller-Myhsok, B Nichols, T Ophoff, R Paus, T Pausova, Z Penninx, B Potkin, S Sämann, P Saykin, A Schumann, G Smoller, J Wardlaw, J Weale, M Martin, N Franke, B Wright, M Thompson, P |
| author_facet | Stein, J Medland, SE Vasquez, A Hibar, D Senstad, R Winkler, A Toro, R Appel, K Bartecek, R Bergmann, Ø Bernard, M Brown, A Cannon, D Chakravarty, M Christoforou, A Domin, M Grimm, O Hollinshead, M Holmes, A Homuth, G Hottenga, J Langan, C Lopez, L Hansell, N Hwang, K Kim, S Laje, G Lee, P Liu, X Loth, E Lourdusamy, A Mattingsdal, M Mohnke, S Maniega, S Nho, K Nugent, A O'Brien, C Papmeyer, M Pütz, B Ramasamy, A Rasmussen, J Rijpkema, M Risacher, S Roddey, J Rose, E Ryten, M Shen, L Sprooten, E Strengman, E Teumer, A Trabzuni, D Turner, J van Eijk, K van Erp, T van Tol, M Wittfeld, K Wolf, C Woudstra, S Aleman, A Alhusaini, S Almasy, L Binder, E Brohawn, D Cantor, R Carless, M Corvin, A Czisch, M Curran, J Davies, G Almeida, d Delanty, N Depondt, C Duggirala, R Dyer, T Erk, S Fagerness, J Fox, P Freimer, N Gill, M Göring, H Hagler, D Hoehn, D Holsboer, F Hoogman, M Hosten, N Jahanshad, N Johnson, M Kasperaviciute, D Kent, J Kochunov, P Lancaster, J Lawrie, S Liewald, D Mandl, R Matarin, M Mattheisen, M Meisenzahl, E Melle, I Moses, E Mühleisen, T Nauck, M Nöthen, M Olvera, R Pandolfo, M Pike, G Puls, R Reinvang, I Rentería, M Rietschel, M Roffman, J Royle, N Rujescu, D Savitz, J Schnack, H Schnell, K Seiferth, N Smith, C Steen, V Hernández, V Van den Heuvel, M van der Wee, N Van Haren, N Veltman, J Völzke, H Walker, R Westlye, LT Whelan, C Agartz, I Boomsma, D Cavalleri, G Dale, A Djurovic, S Drevets, W Hagoort, P Hall, J Heinz, A Jack, C Foroud, T Le Hellard, S Macciardi, F Montgomery, G Poline, J Porteous, D Sisodiya, S Starr, J Sussmann, J Toga, A Veltman, D Walter, H Weiner, M Bis, J Ikram, M Smith, A Gudnason, V Tzourio, C Vernooij, M Launer, L DeCarli, C Seshadri, S Andreassen, O Apostolova, L Bastin, M Blangero, J Brunner, H Buckner, R Cichon, S Coppola, G de Zubicaray, G Deary, I Donohoe, G de Geus, E Espeseth, T Fernández, G Glahn, D Grabe, H Hardy, J Hulshoff Pol, H Jenkinson, M Kahn, R McDonald, C McIntosh, A McMahon, F McMahon, K Meyer-Lindenberg, A Morris, D Müller-Myhsok, B Nichols, T Ophoff, R Paus, T Pausova, Z Penninx, B Potkin, S Sämann, P Saykin, A Schumann, G Smoller, J Wardlaw, J Weale, M Martin, N Franke, B Wright, M Thompson, P |
| author_sort | Stein, J |
| collection | OXFORD |
| description | Identifying genetic variants influencing human brain structures may reveal new biological mechanisms underlying cognition and neuropsychiatric illness. The volume of the hippocampus is a biomarker of incipient Alzheimer's disease and is reduced in schizophrenia, major depression and mesial temporal lobe epilepsy. Whereas many brain imaging phenotypes are highly heritable, identifying and replicating genetic influences has been difficult, as small effects and the high costs of magnetic resonance imaging (MRI) have led to underpowered studies. Here we report genome-wide association meta-analyses and replication for mean bilateral hippocampal, total brain and intracranial volumes from a large multinational consortium. The intergenic variant rs7294919 was associated with hippocampal volume (12q24.22; <em>N</em> = 21,151; <em>P</em> = 6.70 × 10<sup>−16</sup>) and the expression levels of the positional candidate gene TESC in brain tissue. Additionally, rs10784502, located within <em>HMGA2</em>, was associated with intracranial volume (12q14.3; <em>N</em> = 15,782; <em>P</em> = 1.12 × 10<sup>−12</sup>). We also identified a suggestive association with total brain volume at rs10494373 within <em>DDR2</em> (1q23.3; <em>N</em> = 6,500; <em>P</em> = 5.81 × 10<sup>−7</sup>). |
| first_indexed | 2024-03-07T00:36:31Z |
| format | Journal article |
| id | oxford-uuid:819cba79-4870-47e9-85cd-64ae5dfc68a3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:36:31Z |
| publishDate | 2012 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:819cba79-4870-47e9-85cd-64ae5dfc68a32022-03-26T21:31:50ZIdentification of common variants associated with human hippocampal and intracranial volumes.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:819cba79-4870-47e9-85cd-64ae5dfc68a3EnglishSymplectic Elements at OxfordNature Publishing Group2012Stein, JMedland, SEVasquez, AHibar, DSenstad, RWinkler, AToro, RAppel, KBartecek, RBergmann, ØBernard, MBrown, ACannon, DChakravarty, MChristoforou, ADomin, MGrimm, OHollinshead, MHolmes, AHomuth, GHottenga, JLangan, CLopez, LHansell, NHwang, KKim, SLaje, GLee, PLiu, XLoth, ELourdusamy, AMattingsdal, MMohnke, SManiega, SNho, KNugent, AO'Brien, CPapmeyer, MPütz, BRamasamy, ARasmussen, JRijpkema, MRisacher, SRoddey, JRose, ERyten, MShen, LSprooten, EStrengman, ETeumer, ATrabzuni, DTurner, Jvan Eijk, Kvan Erp, Tvan Tol, MWittfeld, KWolf, CWoudstra, SAleman, AAlhusaini, SAlmasy, LBinder, EBrohawn, DCantor, RCarless, MCorvin, ACzisch, MCurran, JDavies, GAlmeida, dDelanty, NDepondt, CDuggirala, RDyer, TErk, SFagerness, JFox, PFreimer, NGill, MGöring, HHagler, DHoehn, DHolsboer, FHoogman, MHosten, NJahanshad, NJohnson, MKasperaviciute, DKent, JKochunov, PLancaster, JLawrie, SLiewald, DMandl, RMatarin, MMattheisen, MMeisenzahl, EMelle, IMoses, EMühleisen, TNauck, MNöthen, MOlvera, RPandolfo, MPike, GPuls, RReinvang, IRentería, MRietschel, MRoffman, JRoyle, NRujescu, DSavitz, JSchnack, HSchnell, KSeiferth, NSmith, CSteen, VHernández, VVan den Heuvel, Mvan der Wee, NVan Haren, NVeltman, JVölzke, HWalker, RWestlye, LTWhelan, CAgartz, IBoomsma, DCavalleri, GDale, ADjurovic, SDrevets, WHagoort, PHall, JHeinz, AJack, CForoud, TLe Hellard, SMacciardi, FMontgomery, GPoline, JPorteous, DSisodiya, SStarr, JSussmann, JToga, AVeltman, DWalter, HWeiner, MBis, JIkram, MSmith, AGudnason, VTzourio, CVernooij, MLauner, LDeCarli, CSeshadri, SAndreassen, OApostolova, LBastin, MBlangero, JBrunner, HBuckner, RCichon, SCoppola, Gde Zubicaray, GDeary, IDonohoe, Gde Geus, EEspeseth, TFernández, GGlahn, DGrabe, HHardy, JHulshoff Pol, HJenkinson, MKahn, RMcDonald, CMcIntosh, AMcMahon, FMcMahon, KMeyer-Lindenberg, AMorris, DMüller-Myhsok, BNichols, TOphoff, RPaus, TPausova, ZPenninx, BPotkin, SSämann, PSaykin, ASchumann, GSmoller, JWardlaw, JWeale, MMartin, NFranke, BWright, MThompson, PIdentifying genetic variants influencing human brain structures may reveal new biological mechanisms underlying cognition and neuropsychiatric illness. The volume of the hippocampus is a biomarker of incipient Alzheimer's disease and is reduced in schizophrenia, major depression and mesial temporal lobe epilepsy. Whereas many brain imaging phenotypes are highly heritable, identifying and replicating genetic influences has been difficult, as small effects and the high costs of magnetic resonance imaging (MRI) have led to underpowered studies. Here we report genome-wide association meta-analyses and replication for mean bilateral hippocampal, total brain and intracranial volumes from a large multinational consortium. The intergenic variant rs7294919 was associated with hippocampal volume (12q24.22; <em>N</em> = 21,151; <em>P</em> = 6.70 × 10<sup>−16</sup>) and the expression levels of the positional candidate gene TESC in brain tissue. Additionally, rs10784502, located within <em>HMGA2</em>, was associated with intracranial volume (12q14.3; <em>N</em> = 15,782; <em>P</em> = 1.12 × 10<sup>−12</sup>). We also identified a suggestive association with total brain volume at rs10494373 within <em>DDR2</em> (1q23.3; <em>N</em> = 6,500; <em>P</em> = 5.81 × 10<sup>−7</sup>). |
| spellingShingle | Stein, J Medland, SE Vasquez, A Hibar, D Senstad, R Winkler, A Toro, R Appel, K Bartecek, R Bergmann, Ø Bernard, M Brown, A Cannon, D Chakravarty, M Christoforou, A Domin, M Grimm, O Hollinshead, M Holmes, A Homuth, G Hottenga, J Langan, C Lopez, L Hansell, N Hwang, K Kim, S Laje, G Lee, P Liu, X Loth, E Lourdusamy, A Mattingsdal, M Mohnke, S Maniega, S Nho, K Nugent, A O'Brien, C Papmeyer, M Pütz, B Ramasamy, A Rasmussen, J Rijpkema, M Risacher, S Roddey, J Rose, E Ryten, M Shen, L Sprooten, E Strengman, E Teumer, A Trabzuni, D Turner, J van Eijk, K van Erp, T van Tol, M Wittfeld, K Wolf, C Woudstra, S Aleman, A Alhusaini, S Almasy, L Binder, E Brohawn, D Cantor, R Carless, M Corvin, A Czisch, M Curran, J Davies, G Almeida, d Delanty, N Depondt, C Duggirala, R Dyer, T Erk, S Fagerness, J Fox, P Freimer, N Gill, M Göring, H Hagler, D Hoehn, D Holsboer, F Hoogman, M Hosten, N Jahanshad, N Johnson, M Kasperaviciute, D Kent, J Kochunov, P Lancaster, J Lawrie, S Liewald, D Mandl, R Matarin, M Mattheisen, M Meisenzahl, E Melle, I Moses, E Mühleisen, T Nauck, M Nöthen, M Olvera, R Pandolfo, M Pike, G Puls, R Reinvang, I Rentería, M Rietschel, M Roffman, J Royle, N Rujescu, D Savitz, J Schnack, H Schnell, K Seiferth, N Smith, C Steen, V Hernández, V Van den Heuvel, M van der Wee, N Van Haren, N Veltman, J Völzke, H Walker, R Westlye, LT Whelan, C Agartz, I Boomsma, D Cavalleri, G Dale, A Djurovic, S Drevets, W Hagoort, P Hall, J Heinz, A Jack, C Foroud, T Le Hellard, S Macciardi, F Montgomery, G Poline, J Porteous, D Sisodiya, S Starr, J Sussmann, J Toga, A Veltman, D Walter, H Weiner, M Bis, J Ikram, M Smith, A Gudnason, V Tzourio, C Vernooij, M Launer, L DeCarli, C Seshadri, S Andreassen, O Apostolova, L Bastin, M Blangero, J Brunner, H Buckner, R Cichon, S Coppola, G de Zubicaray, G Deary, I Donohoe, G de Geus, E Espeseth, T Fernández, G Glahn, D Grabe, H Hardy, J Hulshoff Pol, H Jenkinson, M Kahn, R McDonald, C McIntosh, A McMahon, F McMahon, K Meyer-Lindenberg, A Morris, D Müller-Myhsok, B Nichols, T Ophoff, R Paus, T Pausova, Z Penninx, B Potkin, S Sämann, P Saykin, A Schumann, G Smoller, J Wardlaw, J Weale, M Martin, N Franke, B Wright, M Thompson, P Identification of common variants associated with human hippocampal and intracranial volumes. |
| title | Identification of common variants associated with human hippocampal and intracranial volumes. |
| title_full | Identification of common variants associated with human hippocampal and intracranial volumes. |
| title_fullStr | Identification of common variants associated with human hippocampal and intracranial volumes. |
| title_full_unstemmed | Identification of common variants associated with human hippocampal and intracranial volumes. |
| title_short | Identification of common variants associated with human hippocampal and intracranial volumes. |
| title_sort | identification of common variants associated with human hippocampal and intracranial volumes |
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identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT polinej identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT porteousd identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT sisodiyas identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT starrj identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT sussmannj identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT togaa identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT veltmand identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT walterh identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT weinerm identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT bisj identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT ikramm identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT smitha identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT gudnasonv identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT tzourioc identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT vernooijm identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT launerl identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT decarlic identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT seshadris identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT andreasseno identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT apostoloval identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT bastinm identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT blangeroj identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT brunnerh identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT bucknerr identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT cichons identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT coppolag identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT dezubicarayg identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT dearyi identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT donohoeg identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT degeuse identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT espesetht identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT fernandezg identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT glahnd identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT grabeh identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT hardyj identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT hulshoffpolh identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT jenkinsonm identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT kahnr identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT mcdonaldc identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT mcintosha identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT mcmahonf identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT mcmahonk identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT meyerlindenberga identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT morrisd identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT mullermyhsokb identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT nicholst identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT ophoffr identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT paust identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT pausovaz identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT penninxb identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT potkins identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT samannp identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT saykina identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT schumanng identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT smollerj identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT wardlawj identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT wealem identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT martinn identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT frankeb identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT wrightm identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes AT thompsonp identificationofcommonvariantsassociatedwithhumanhippocampalandintracranialvolumes |