Ivermectin inhibits molting of Wuchereria bancrofti third stage larvae in vitro.
The effect of ivermectin or diethylcarbamazine (DEC) on Wuchereria bancrofti molting from the third to the fourth larval stage (L3 to L4) was evaluated in vitro. L3 larvae were harvested from laboratory-reared Aedes togoi 2 wk after feeding upon a microfilaremic human volunteer. The larvae were kept...
| Egile Nagusiak: | , , , |
|---|---|
| Formatua: | Journal article |
| Hizkuntza: | English |
| Argitaratua: |
1991
|
| _version_ | 1826282011481866240 |
|---|---|
| author | Baird, J Riberu, W Masbar, S Purnomo |
| author_facet | Baird, J Riberu, W Masbar, S Purnomo |
| author_sort | Baird, J |
| collection | OXFORD |
| description | The effect of ivermectin or diethylcarbamazine (DEC) on Wuchereria bancrofti molting from the third to the fourth larval stage (L3 to L4) was evaluated in vitro. L3 larvae were harvested from laboratory-reared Aedes togoi 2 wk after feeding upon a microfilaremic human volunteer. The larvae were kept in an artificial medium (Franke's NI medium) with 10% human serum under an atmosphere of 5% CO2 for 20 days. Experimental tubes also contained ivermectin (0.1-1,000 ng/ml) or DEC (0.1-10,000 ng/ml). An estimated concentration of 50 ng/ml ivermectin inhibited molting in 50% of the larvae expected to molt. For DEC, this value was roughly 1,000 ng/ml. In this in vitro culture system, ivermectin inhibited the L3 to L4 molt of W. bancrofti and was roughly 20-fold more potent in this activity than DEC. |
| first_indexed | 2024-03-07T00:37:26Z |
| format | Journal article |
| id | oxford-uuid:81e83175-d13e-4f2b-921f-e4e4af465fc4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:37:26Z |
| publishDate | 1991 |
| record_format | dspace |
| spelling | oxford-uuid:81e83175-d13e-4f2b-921f-e4e4af465fc42022-03-26T21:33:36ZIvermectin inhibits molting of Wuchereria bancrofti third stage larvae in vitro.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:81e83175-d13e-4f2b-921f-e4e4af465fc4EnglishSymplectic Elements at Oxford1991Baird, JRiberu, WMasbar, SPurnomoThe effect of ivermectin or diethylcarbamazine (DEC) on Wuchereria bancrofti molting from the third to the fourth larval stage (L3 to L4) was evaluated in vitro. L3 larvae were harvested from laboratory-reared Aedes togoi 2 wk after feeding upon a microfilaremic human volunteer. The larvae were kept in an artificial medium (Franke's NI medium) with 10% human serum under an atmosphere of 5% CO2 for 20 days. Experimental tubes also contained ivermectin (0.1-1,000 ng/ml) or DEC (0.1-10,000 ng/ml). An estimated concentration of 50 ng/ml ivermectin inhibited molting in 50% of the larvae expected to molt. For DEC, this value was roughly 1,000 ng/ml. In this in vitro culture system, ivermectin inhibited the L3 to L4 molt of W. bancrofti and was roughly 20-fold more potent in this activity than DEC. |
| spellingShingle | Baird, J Riberu, W Masbar, S Purnomo Ivermectin inhibits molting of Wuchereria bancrofti third stage larvae in vitro. |
| title | Ivermectin inhibits molting of Wuchereria bancrofti third stage larvae in vitro. |
| title_full | Ivermectin inhibits molting of Wuchereria bancrofti third stage larvae in vitro. |
| title_fullStr | Ivermectin inhibits molting of Wuchereria bancrofti third stage larvae in vitro. |
| title_full_unstemmed | Ivermectin inhibits molting of Wuchereria bancrofti third stage larvae in vitro. |
| title_short | Ivermectin inhibits molting of Wuchereria bancrofti third stage larvae in vitro. |
| title_sort | ivermectin inhibits molting of wuchereria bancrofti third stage larvae in vitro |
| work_keys_str_mv | AT bairdj ivermectininhibitsmoltingofwuchereriabancroftithirdstagelarvaeinvitro AT riberuw ivermectininhibitsmoltingofwuchereriabancroftithirdstagelarvaeinvitro AT masbars ivermectininhibitsmoltingofwuchereriabancroftithirdstagelarvaeinvitro AT purnomo ivermectininhibitsmoltingofwuchereriabancroftithirdstagelarvaeinvitro |