Hypothalamic and brainstem glucose-dependent insulinotropic polypeptide receptor neurons employ distinct mechanisms to affect feeding

Hypothalamic and brainstem glucose-dependent insulinotropic polypeptide receptor neurons employ distinct mechanisms to affect feeding

Central glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) signaling is critical in GIP-based therapeutics’ ability to lower body weight, but pathways leveraged by GIPR pharmacology in the brain remain incompletely understood. We explored the role of Gipr neurons in the hypothalamus...

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Bibliographic Details
Main Authors: Adriaenssens, A, Broichhagen, J, de Bray, A, Ast, J, Hasib, A, Jones, B, Tomas, A, Figueredo Burgos, N, Woodward, O, Lewis, J, O’Flaherty, E, El, K, Cui, C, Horada, N, Inagaki, N, Campbell, J, Brierley, D, Hodson, DJ, Samms, R, Gribble, F, Reimann, F
Format: Journal article
Language:English
Published: American Society for Clinical Investigation 2023

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