Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease

Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease

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<p style="text-align:justify;"> We report results of a nonsynonymous SNP scan for ulcerative colitis and identify a previously unknown susceptibility locus at ECM1. We also show that several risk loci are common to ulcerative colitis and Crohn's disease (IL23R, IL12B, HLA, NKX2...

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Bibliographic Details
Main Authors: Fisher, SA, Tremelling, M, Anderson, CA, Gwilliam, R, Bumpstead, S, Prescott, NJ, Nimmo, ER, Massey, D, Berzuini, C, Johnson, C, Barrett, JC, Cummings, FR, Drummond, H, Lees, CW, Onnie, CM, Hanson, CE, Blaszczyk, K, Inouye, M, Ewels, P, Ravindrarajah, R, Keniry, A, Hunt, S, Carter, M, Watkins, N, Ouwehand, W, Lewis, CM, Cardon, L, Lobo, A, Forbes, A, Sanderson, J, Jewell, DP, Mansfield, JC, Deloukas, P, Mathew, CG, Parkes, M, Satsangi, J
Format: Journal article
Language:English
Published: Springer Nature 2008

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