Comprehensive epigenomic profiling reveals the extent of disease-specific chromatin states and informs target discovery in ankylosing spondylitis

Comprehensive epigenomic profiling reveals the extent of disease-specific chromatin states and informs target discovery in ankylosing spondylitis

Ankylosing spondylitis (AS) is a common, highly heritable inflammatory arthritis characterized by enthesitis of the spine and sacroiliac joints. Genome-wide association studies (GWASs) have revealed more than 100 genetic associations whose functional effects remain largely unresolved. Here, we prese...

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Manylion Llyfryddiaeth
Prif Awduron:	Brown, AC, Cohen, CJ, Mielczarek, O, Migliorini, G, Costantino, F, Allcock, A, Davidson, C, Elliott, KS, Fang, H, Lledó Lara, A, Martin, AC, Osgood, JA, Sanniti, A, Scozzafava, G, Vecellio, M, Zhang, P, Black, MH, Li, S, Truong, D, Molineros, J, Howe, T, Wordsworth, BP, Bowness, P, Knight, JC
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	Cell Press 2023

Eitemau Tebyg

Perspectives on the genetic associations of ankylosing spondylitis
gan: Wordsworth, BP, et al.
Cyhoeddwyd: (2021)

Functional genomics of Ankylosing Spondylitis
gan: Sanniti, A
Cyhoeddwyd: (2017)

FROM SNPs TO FUNCTION: TRANSCRIPTIONAL REGULATION OF RUNX3 IN ANKYLOSING SPONDYLITIS
gan: Vecellio, M, et al.
Cyhoeddwyd: (2014)

Perspectives on the Genetic Associations of Ankylosing Spondylitis
gan: B. Paul Wordsworth, et al.
Cyhoeddwyd: (2021-03-01)

The genetic association of RUNX3 with ankylosing spondylitis can be explained by allele-specific effects on IRF4 recruitment that alter gene expression
gan: Vecellio, M, et al.
Cyhoeddwyd: (2015)

ANKYLOSING SPONDYLITIS-ASSOCIATED SNPS AT THE IL23R-IL12RB2 INTERGENIC REGION ARE FUNCTIONALLY IMPORTANT
gan: Roberts, A, et al.
Cyhoeddwyd: (2014)

Disruption of c-MYC binding and chromosomal looping involving genetic variants associated with ankylosing spondylitis upstream of the RUNX3 promoter
gan: Cohen, CJ, et al.
Cyhoeddwyd: (2022)

THU0364 Rare ERAP1 allotype combinations do not explain the ERAP1 association with ankylosing spondylitis
gan: Appleton, LH, et al.
Cyhoeddwyd: (2016)

Evidence for a second ankylosing spondylitis-associated RUNX3 regulatory polymorphism
gan: Vecellio, M, et al.
Cyhoeddwyd: (2018)

The immunology of Ankylosing Spondylitis
gan: Bowness, P
Cyhoeddwyd: (2011)

OP0299 Susceptibility to ankylosing spondylitis is influenced independently by two closely adjacent Runx3 Snps, that show strong functional effect in different cell types
gan: Vecellio, ML, et al.
Cyhoeddwyd: (2016)

Reply to Reeves et al.: No evidence for rare ERAP1 haplotypes and haplotype combinations in ankylosing spondylitis
gan: Wordsworth, B, et al.
Cyhoeddwyd: (2017)

MRI CHANGES IN THE CERVICAL SPINE IN PATIENTS WITH ANKYLOSING SPONDYLITIS
gan: Holden, W, et al.
Cyhoeddwyd: (2003)

ANKYLOSING-SPONDYLITIS AND FUNCTIONAL ABILITY
gan: Wordsworth, B, et al.
Cyhoeddwyd: (1984)

RUNX3 and T-Bet in immunopathogenesis of ankylosing spondylitis—novel targets for therapy?
gan: Vecellio, M, et al.
Cyhoeddwyd: (2019)

OVERVIEW OF ANKYLOSING SPONDYLITIS GENETICS AND PATHOGENESIS
gan: Bowness, P
Cyhoeddwyd: (2012)

Functional genomic analysis of a RUNX3 polymorphism associated with ankylosing spondylitis
gan: Vecellio, M, et al.
Cyhoeddwyd: (2021)

Genetic susceptibility to ankylosing spondylitis.
gan: Sims, A, et al.
Cyhoeddwyd: (2004)

An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation
gan: Roberts, AR, et al.
Cyhoeddwyd: (2016)

Genetics of ankylosing spondylitis.
gan: Brown, M, et al.
Cyhoeddwyd: (2002)

Mapping the epigenomic landscape of human monocytes following innate immune activation reveals context-specific mechanisms driving endotoxin tolerance
gan: Amarasinghe, HE, et al.
Cyhoeddwyd: (2023)

Secretor status and ankylosing spondylitis.
gan: Pal, A, et al.
Cyhoeddwyd: (1998)

AN INVESTIGATION INTO NECK PAIN, CLINICAL AND FUNCTIONAL INDICES, AND DRIVING IN ANKYLOSING SPONDYLITIS
gan: Holden, W, et al.
Cyhoeddwyd: (2002)

EPIGENETIC REGULATION OF THE IL-23R LOCUS IN ANKYLOSING SPONDYLITIS
gan: Cohen, C, et al.
Cyhoeddwyd: (2013)

Hypophosphataemia masquerading as ankylosing spondylitis
gan: Wordsworth, B, et al.
Cyhoeddwyd: (2008)

Functional characterization of ankylosing spondylitis genetic risk variants
gan: Osgood, JA
Cyhoeddwyd: (2019)

Susceptibility to ankylosing spondylitis.
gan: Carter, N, et al.
Cyhoeddwyd: (2000)

New developments in our understanding of Ankylosing Spondylitis pathogenesis
gan: Voruganti, A, et al.
Cyhoeddwyd: (2020)

THE ROLE OF ANKH IN ANKYLOSING SPONDYLITIS
gan: Timms, A, et al.
Cyhoeddwyd: (2003)

COEXISTENT TOPHACEOUS GOUT AND ANKYLOSING-SPONDYLITIS
gan: Portek, I, et al.
Cyhoeddwyd: (1983)

Investigation of a possible extended risk haplotype in the IL23R region associated with ankylosing spondylitis
gan: Roberts, A, et al.
Cyhoeddwyd: (2017)

Chromosome conformation capture approaches to investigate 3D genome architecture in Ankylosing Spondylitis
gan: Connor Davidson, et al.
Cyhoeddwyd: (2023-01-01)

OP0231 Differential transcription factor binding could explain the genetic association of ankylosing spondylitis with polymorphisms in the IL23R-IL12RB2 intergenic region
gan: Roberts, AR, et al.
Cyhoeddwyd: (2016)

ERAP1 and ankylosing spondylitis.
gan: Keidel, S, et al.
Cyhoeddwyd: (2013)

Susceptibility to ankylosing spondylitis is influenced independently by two closely adjacent RUNX3 single nucleotide polymorphisms that show strong functional effect in different cell types
gan: Vecellio, M, et al.
Cyhoeddwyd: (2016)

The X-chromosome and susceptibility to ankylosing spondylitis.
gan: Hoyle, E, et al.
Cyhoeddwyd: (2000)

Interleukin-1 and susceptibility to ankylosing spondylitis
gan: Edwards, S, et al.
Cyhoeddwyd: (2001)

Neck pain is a major clinical problem in ankylosing spondylitis, and impacts on driving and safety.
gan: Holden, W, et al.
Cyhoeddwyd: (2005)

Investigation of the role of ANKH in ankylosing spondylitis.
gan: Timms, A, et al.
Cyhoeddwyd: (2003)

MicroRNAs in ankylosing spondylitis: Function, potential and challenges
gan: Francesca Motta, et al.
Cyhoeddwyd: (2020-01-01)