Comprehensive epigenomic profiling reveals the extent of disease-specific chromatin states and informs target discovery in ankylosing spondylitis

Comprehensive epigenomic profiling reveals the extent of disease-specific chromatin states and informs target discovery in ankylosing spondylitis

Ankylosing spondylitis (AS) is a common, highly heritable inflammatory arthritis characterized by enthesitis of the spine and sacroiliac joints. Genome-wide association studies (GWASs) have revealed more than 100 genetic associations whose functional effects remain largely unresolved. Here, we prese...

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Bibliografiske detaljer
Main Authors:	Brown, AC, Cohen, CJ, Mielczarek, O, Migliorini, G, Costantino, F, Allcock, A, Davidson, C, Elliott, KS, Fang, H, Lledó Lara, A, Martin, AC, Osgood, JA, Sanniti, A, Scozzafava, G, Vecellio, M, Zhang, P, Black, MH, Li, S, Truong, D, Molineros, J, Howe, T, Wordsworth, BP, Bowness, P, Knight, JC
Format:	Journal article
Sprog:	English
Udgivet:	Cell Press 2023

Lignende værker

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Udgivet: (2021)

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Udgivet: (2017)

FROM SNPs TO FUNCTION: TRANSCRIPTIONAL REGULATION OF RUNX3 IN ANKYLOSING SPONDYLITIS
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Udgivet: (2014)

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Udgivet: (2021-03-01)

The genetic association of RUNX3 with ankylosing spondylitis can be explained by allele-specific effects on IRF4 recruitment that alter gene expression
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Udgivet: (2015)

ANKYLOSING SPONDYLITIS-ASSOCIATED SNPS AT THE IL23R-IL12RB2 INTERGENIC REGION ARE FUNCTIONALLY IMPORTANT
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Udgivet: (2022)

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Udgivet: (2016)

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Susceptibility to ankylosing spondylitis is influenced independently by two closely adjacent RUNX3 single nucleotide polymorphisms that show strong functional effect in different cell types
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