Comprehensive epigenomic profiling reveals the extent of disease-specific chromatin states and informs target discovery in ankylosing spondylitis

Comprehensive epigenomic profiling reveals the extent of disease-specific chromatin states and informs target discovery in ankylosing spondylitis

Ankylosing spondylitis (AS) is a common, highly heritable inflammatory arthritis characterized by enthesitis of the spine and sacroiliac joints. Genome-wide association studies (GWASs) have revealed more than 100 genetic associations whose functional effects remain largely unresolved. Here, we prese...

Bibliografski detalji
Glavni autori:	Brown, AC, Cohen, CJ, Mielczarek, O, Migliorini, G, Costantino, F, Allcock, A, Davidson, C, Elliott, KS, Fang, H, Lledó Lara, A, Martin, AC, Osgood, JA, Sanniti, A, Scozzafava, G, Vecellio, M, Zhang, P, Black, MH, Li, S, Truong, D, Molineros, J, Howe, T, Wordsworth, BP, Bowness, P, Knight, JC
Format:	Journal article
Jezik:	English
Izdano:	Cell Press 2023

Slični predmeti

Perspectives on the genetic associations of ankylosing spondylitis
od: Wordsworth, BP, i dr.
Izdano: (2021)

Functional genomics of Ankylosing Spondylitis
od: Sanniti, A
Izdano: (2017)

FROM SNPs TO FUNCTION: TRANSCRIPTIONAL REGULATION OF RUNX3 IN ANKYLOSING SPONDYLITIS
od: Vecellio, M, i dr.
Izdano: (2014)

Perspectives on the Genetic Associations of Ankylosing Spondylitis
od: B. Paul Wordsworth, i dr.
Izdano: (2021-03-01)

The genetic association of RUNX3 with ankylosing spondylitis can be explained by allele-specific effects on IRF4 recruitment that alter gene expression
od: Vecellio, M, i dr.
Izdano: (2015)

ANKYLOSING SPONDYLITIS-ASSOCIATED SNPS AT THE IL23R-IL12RB2 INTERGENIC REGION ARE FUNCTIONALLY IMPORTANT
od: Roberts, A, i dr.
Izdano: (2014)

Disruption of c-MYC binding and chromosomal looping involving genetic variants associated with ankylosing spondylitis upstream of the RUNX3 promoter
od: Cohen, CJ, i dr.
Izdano: (2022)

THU0364 Rare ERAP1 allotype combinations do not explain the ERAP1 association with ankylosing spondylitis
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Izdano: (2016)

Evidence for a second ankylosing spondylitis-associated RUNX3 regulatory polymorphism
od: Vecellio, M, i dr.
Izdano: (2018)

The immunology of Ankylosing Spondylitis
od: Bowness, P
Izdano: (2011)

OP0299 Susceptibility to ankylosing spondylitis is influenced independently by two closely adjacent Runx3 Snps, that show strong functional effect in different cell types
od: Vecellio, ML, i dr.
Izdano: (2016)

Reply to Reeves et al.: No evidence for rare ERAP1 haplotypes and haplotype combinations in ankylosing spondylitis
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Izdano: (2017)

MRI CHANGES IN THE CERVICAL SPINE IN PATIENTS WITH ANKYLOSING SPONDYLITIS
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Izdano: (2003)

ANKYLOSING-SPONDYLITIS AND FUNCTIONAL ABILITY
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Izdano: (1984)

RUNX3 and T-Bet in immunopathogenesis of ankylosing spondylitis—novel targets for therapy?
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Izdano: (2019)

OVERVIEW OF ANKYLOSING SPONDYLITIS GENETICS AND PATHOGENESIS
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Izdano: (2012)

Functional genomic analysis of a RUNX3 polymorphism associated with ankylosing spondylitis
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Izdano: (2021)

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An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation
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Mapping the epigenomic landscape of human monocytes following innate immune activation reveals context-specific mechanisms driving endotoxin tolerance
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Izdano: (2023)

Secretor status and ankylosing spondylitis.
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Izdano: (1998)

AN INVESTIGATION INTO NECK PAIN, CLINICAL AND FUNCTIONAL INDICES, AND DRIVING IN ANKYLOSING SPONDYLITIS
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Izdano: (2002)

EPIGENETIC REGULATION OF THE IL-23R LOCUS IN ANKYLOSING SPONDYLITIS
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Izdano: (2013)

Hypophosphataemia masquerading as ankylosing spondylitis
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Izdano: (2008)

Functional characterization of ankylosing spondylitis genetic risk variants
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Izdano: (2019)

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New developments in our understanding of Ankylosing Spondylitis pathogenesis
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Izdano: (2020)

THE ROLE OF ANKH IN ANKYLOSING SPONDYLITIS
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COEXISTENT TOPHACEOUS GOUT AND ANKYLOSING-SPONDYLITIS
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Izdano: (1983)

Investigation of a possible extended risk haplotype in the IL23R region associated with ankylosing spondylitis
od: Roberts, A, i dr.
Izdano: (2017)

Chromosome conformation capture approaches to investigate 3D genome architecture in Ankylosing Spondylitis
od: Connor Davidson, i dr.
Izdano: (2023-01-01)

OP0231 Differential transcription factor binding could explain the genetic association of ankylosing spondylitis with polymorphisms in the IL23R-IL12RB2 intergenic region
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Izdano: (2016)

ERAP1 and ankylosing spondylitis.
od: Keidel, S, i dr.
Izdano: (2013)

Susceptibility to ankylosing spondylitis is influenced independently by two closely adjacent RUNX3 single nucleotide polymorphisms that show strong functional effect in different cell types
od: Vecellio, M, i dr.
Izdano: (2016)

The X-chromosome and susceptibility to ankylosing spondylitis.
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Interleukin-1 and susceptibility to ankylosing spondylitis
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Neck pain is a major clinical problem in ankylosing spondylitis, and impacts on driving and safety.
od: Holden, W, i dr.
Izdano: (2005)

Investigation of the role of ANKH in ankylosing spondylitis.
od: Timms, A, i dr.
Izdano: (2003)

MicroRNAs in ankylosing spondylitis: Function, potential and challenges
od: Francesca Motta, i dr.
Izdano: (2020-01-01)