Comprehensive epigenomic profiling reveals the extent of disease-specific chromatin states and informs target discovery in ankylosing spondylitis
Ankylosing spondylitis (AS) is a common, highly heritable inflammatory arthritis characterized by enthesitis of the spine and sacroiliac joints. Genome-wide association studies (GWASs) have revealed more than 100 genetic associations whose functional effects remain largely unresolved. Here, we prese...
Հիմնական հեղինակներ: | Brown, AC, Cohen, CJ, Mielczarek, O, Migliorini, G, Costantino, F, Allcock, A, Davidson, C, Elliott, KS, Fang, H, Lledó Lara, A, Martin, AC, Osgood, JA, Sanniti, A, Scozzafava, G, Vecellio, M, Zhang, P, Black, MH, Li, S, Truong, D, Molineros, J, Howe, T, Wordsworth, BP, Bowness, P, Knight, JC |
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Ձևաչափ: | Journal article |
Լեզու: | English |
Հրապարակվել է: |
Cell Press
2023
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Նմանատիպ նյութեր
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Perspectives on the genetic associations of ankylosing spondylitis
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Functional genomics of Ankylosing Spondylitis
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FROM SNPs TO FUNCTION: TRANSCRIPTIONAL REGULATION OF RUNX3 IN ANKYLOSING SPONDYLITIS
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Perspectives on the Genetic Associations of Ankylosing Spondylitis
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The genetic association of RUNX3 with ankylosing spondylitis can be explained by allele-specific effects on IRF4 recruitment that alter gene expression
: Vecellio, M, և այլն
Հրապարակվել է: (2015)