Comprehensive epigenomic profiling reveals the extent of disease-specific chromatin states and informs target discovery in ankylosing spondylitis

Comprehensive epigenomic profiling reveals the extent of disease-specific chromatin states and informs target discovery in ankylosing spondylitis

Ankylosing spondylitis (AS) is a common, highly heritable inflammatory arthritis characterized by enthesitis of the spine and sacroiliac joints. Genome-wide association studies (GWASs) have revealed more than 100 genetic associations whose functional effects remain largely unresolved. Here, we prese...

書誌詳細
主要な著者:	Brown, AC, Cohen, CJ, Mielczarek, O, Migliorini, G, Costantino, F, Allcock, A, Davidson, C, Elliott, KS, Fang, H, Lledó Lara, A, Martin, AC, Osgood, JA, Sanniti, A, Scozzafava, G, Vecellio, M, Zhang, P, Black, MH, Li, S, Truong, D, Molineros, J, Howe, T, Wordsworth, BP, Bowness, P, Knight, JC
フォーマット:	Journal article
言語:	English
出版事項:	Cell Press 2023

類似資料

Perspectives on the genetic associations of ankylosing spondylitis
著者:: Wordsworth, BP, 等
出版事項: (2021)

Functional genomics of Ankylosing Spondylitis
著者:: Sanniti, A
出版事項: (2017)

FROM SNPs TO FUNCTION: TRANSCRIPTIONAL REGULATION OF RUNX3 IN ANKYLOSING SPONDYLITIS
著者:: Vecellio, M, 等
出版事項: (2014)

Perspectives on the Genetic Associations of Ankylosing Spondylitis
著者:: B. Paul Wordsworth, 等
出版事項: (2021-03-01)

The genetic association of RUNX3 with ankylosing spondylitis can be explained by allele-specific effects on IRF4 recruitment that alter gene expression
著者:: Vecellio, M, 等
出版事項: (2015)

ANKYLOSING SPONDYLITIS-ASSOCIATED SNPS AT THE IL23R-IL12RB2 INTERGENIC REGION ARE FUNCTIONALLY IMPORTANT
著者:: Roberts, A, 等
出版事項: (2014)

Disruption of c-MYC binding and chromosomal looping involving genetic variants associated with ankylosing spondylitis upstream of the RUNX3 promoter
著者:: Cohen, CJ, 等
出版事項: (2022)

THU0364 Rare ERAP1 allotype combinations do not explain the ERAP1 association with ankylosing spondylitis
著者:: Appleton, LH, 等
出版事項: (2016)

Evidence for a second ankylosing spondylitis-associated RUNX3 regulatory polymorphism
著者:: Vecellio, M, 等
出版事項: (2018)

The immunology of Ankylosing Spondylitis
著者:: Bowness, P
出版事項: (2011)

OP0299 Susceptibility to ankylosing spondylitis is influenced independently by two closely adjacent Runx3 Snps, that show strong functional effect in different cell types
著者:: Vecellio, ML, 等
出版事項: (2016)

Reply to Reeves et al.: No evidence for rare ERAP1 haplotypes and haplotype combinations in ankylosing spondylitis
著者:: Wordsworth, B, 等
出版事項: (2017)

MRI CHANGES IN THE CERVICAL SPINE IN PATIENTS WITH ANKYLOSING SPONDYLITIS
著者:: Holden, W, 等
出版事項: (2003)

ANKYLOSING-SPONDYLITIS AND FUNCTIONAL ABILITY
著者:: Wordsworth, B, 等
出版事項: (1984)

RUNX3 and T-Bet in immunopathogenesis of ankylosing spondylitis—novel targets for therapy?
著者:: Vecellio, M, 等
出版事項: (2019)

OVERVIEW OF ANKYLOSING SPONDYLITIS GENETICS AND PATHOGENESIS
著者:: Bowness, P
出版事項: (2012)

Functional genomic analysis of a RUNX3 polymorphism associated with ankylosing spondylitis
著者:: Vecellio, M, 等
出版事項: (2021)

Genetic susceptibility to ankylosing spondylitis.
著者:: Sims, A, 等
出版事項: (2004)

An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation
著者:: Roberts, AR, 等
出版事項: (2016)

Genetics of ankylosing spondylitis.
著者:: Brown, M, 等
出版事項: (2002)

Mapping the epigenomic landscape of human monocytes following innate immune activation reveals context-specific mechanisms driving endotoxin tolerance
著者:: Amarasinghe, HE, 等
出版事項: (2023)

Secretor status and ankylosing spondylitis.
著者:: Pal, A, 等
出版事項: (1998)

AN INVESTIGATION INTO NECK PAIN, CLINICAL AND FUNCTIONAL INDICES, AND DRIVING IN ANKYLOSING SPONDYLITIS
著者:: Holden, W, 等
出版事項: (2002)

EPIGENETIC REGULATION OF THE IL-23R LOCUS IN ANKYLOSING SPONDYLITIS
著者:: Cohen, C, 等
出版事項: (2013)

Hypophosphataemia masquerading as ankylosing spondylitis
著者:: Wordsworth, B, 等
出版事項: (2008)

Functional characterization of ankylosing spondylitis genetic risk variants
著者:: Osgood, JA
出版事項: (2019)

Susceptibility to ankylosing spondylitis.
著者:: Carter, N, 等
出版事項: (2000)

New developments in our understanding of Ankylosing Spondylitis pathogenesis
著者:: Voruganti, A, 等
出版事項: (2020)

THE ROLE OF ANKH IN ANKYLOSING SPONDYLITIS
著者:: Timms, A, 等
出版事項: (2003)

COEXISTENT TOPHACEOUS GOUT AND ANKYLOSING-SPONDYLITIS
著者:: Portek, I, 等
出版事項: (1983)

Investigation of a possible extended risk haplotype in the IL23R region associated with ankylosing spondylitis
著者:: Roberts, A, 等
出版事項: (2017)

Chromosome conformation capture approaches to investigate 3D genome architecture in Ankylosing Spondylitis
著者:: Connor Davidson, 等
出版事項: (2023-01-01)

OP0231 Differential transcription factor binding could explain the genetic association of ankylosing spondylitis with polymorphisms in the IL23R-IL12RB2 intergenic region
著者:: Roberts, AR, 等
出版事項: (2016)

ERAP1 and ankylosing spondylitis.
著者:: Keidel, S, 等
出版事項: (2013)

Susceptibility to ankylosing spondylitis is influenced independently by two closely adjacent RUNX3 single nucleotide polymorphisms that show strong functional effect in different cell types
著者:: Vecellio, M, 等
出版事項: (2016)

The X-chromosome and susceptibility to ankylosing spondylitis.
著者:: Hoyle, E, 等
出版事項: (2000)

Interleukin-1 and susceptibility to ankylosing spondylitis
著者:: Edwards, S, 等
出版事項: (2001)

Neck pain is a major clinical problem in ankylosing spondylitis, and impacts on driving and safety.
著者:: Holden, W, 等
出版事項: (2005)

Investigation of the role of ANKH in ankylosing spondylitis.
著者:: Timms, A, 等
出版事項: (2003)

MicroRNAs in ankylosing spondylitis: Function, potential and challenges
著者:: Francesca Motta, 等
出版事項: (2020-01-01)