Progression to AIDS in South Africa is associated with both reverting and compensatory viral mutations.

Progression to AIDS in South Africa is associated with both reverting and compensatory viral mutations.

We lack the understanding of why HIV-infected individuals in South Africa progress to AIDS. We hypothesised that in end-stage disease there is a shifting dynamic between T cell imposed immunity and viral immune escape, which, through both compensatory and reverting viral mutations, results in increa...

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Bibliographic Details
Main Authors:	Huang, K, Goedhals, D, Carlson, J, Brockman, M, Mishra, S, Brumme, Z, Hickling, S, Tang, C, Miura, T, Seebregts, C, Heckerman, D, Ndung'u, T, Walker, B, Klenerman, P, Steyn, D, Goulder, P, Phillips, R, van Vuuren, C, Frater, A
Format:	Journal article
Language:	English
Published:	Public Library of Science 2011

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