Progression to AIDS in South Africa is associated with both reverting and compensatory viral mutations.

We lack the understanding of why HIV-infected individuals in South Africa progress to AIDS. We hypothesised that in end-stage disease there is a shifting dynamic between T cell imposed immunity and viral immune escape, which, through both compensatory and reverting viral mutations, results in increa...

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Váldodahkkit: Huang, K, Goedhals, D, Carlson, J, Brockman, M, Mishra, S, Brumme, Z, Hickling, S, Tang, C, Miura, T, Seebregts, C, Heckerman, D, Ndung'u, T, Walker, B, Klenerman, P, Steyn, D, Goulder, P, Phillips, R, van Vuuren, C, Frater, A
Materiálatiipa: Journal article
Giella:English
Almmustuhtton: Public Library of Science 2011