Small-molecule Polθ inhibitors provide safe and effective tumor radiosensitization in preclinical models

Small-molecule Polθ inhibitors provide safe and effective tumor radiosensitization in preclinical models

<p><strong>Purpose:</strong> DNA polymerase theta (Polθ, encoded by the POLQ gene) is a DNA repair enzyme critical for microhomology mediated end joining (MMEJ). Polθ has limited expression in normal tissues but is frequently overexpressed in cancer cells and, therefore, represents...

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主要な著者: Rodriguez-Berriguete, G, Ranzani, M, Prevo, R, Puliyadi, R, Machado, N, Bolland, HR, Millar, V, Ebner, D, Boursier, M, Cerutti, A, Cicconi, A, Galbiati, A, Grande, D, Grinkevich, V, Majithiya, J, Piscitello, D, Rajendra, E, Stockley, M, Boulton, SJ, Heald, R, Hammond, EM, Smith, GCM, Robinson, H, Higgins, GS
フォーマット: Journal article
言語:English
出版事項: American Association for Cancer Research 2023

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