Small-molecule Polθ inhibitors provide safe and effective tumor radiosensitization in preclinical models

Small-molecule Polθ inhibitors provide safe and effective tumor radiosensitization in preclinical models

<p><strong>Purpose:</strong> DNA polymerase theta (Polθ, encoded by the POLQ gene) is a DNA repair enzyme critical for microhomology mediated end joining (MMEJ). Polθ has limited expression in normal tissues but is frequently overexpressed in cancer cells and, therefore, represents...

Full beskrivning

Bibliografiska uppgifter
Huvudupphovsmän: Rodriguez-Berriguete, G, Ranzani, M, Prevo, R, Puliyadi, R, Machado, N, Bolland, HR, Millar, V, Ebner, D, Boursier, M, Cerutti, A, Cicconi, A, Galbiati, A, Grande, D, Grinkevich, V, Majithiya, J, Piscitello, D, Rajendra, E, Stockley, M, Boulton, SJ, Heald, R, Hammond, EM, Smith, GCM, Robinson, H, Higgins, GS
Materialtyp: Journal article
Språk:English
Publicerad: American Association for Cancer Research 2023

Liknande verk