Characterization of a widely expressed gene (LUC7-LIKE; LUC7L) defining the centromeric boundary of the human alpha-globin domain.
We have identified the first gene lying on the centromeric side of the alpha-globin gene cluster on human 16p13.3. The gene, called 16pHQG;16 (HGMW-approved symbol LUC7L), is widely transcribed and lies in the opposite orientation with respect to the alpha-globin genes. This gene may represent a mam...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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2001
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| _version_ | 1797078974283644928 |
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| author | Tufarelli, C Frischauf, A Hardison, R Flint, J Higgs, D |
| author_facet | Tufarelli, C Frischauf, A Hardison, R Flint, J Higgs, D |
| author_sort | Tufarelli, C |
| collection | OXFORD |
| description | We have identified the first gene lying on the centromeric side of the alpha-globin gene cluster on human 16p13.3. The gene, called 16pHQG;16 (HGMW-approved symbol LUC7L), is widely transcribed and lies in the opposite orientation with respect to the alpha-globin genes. This gene may represent a mammalian heterochromatic gene, encoding a putative RNA-binding protein similar to the yeast Luc7p subunit of the U1 snRNP splicing complex that is normally required for 5' splice site selection. To examine the role of the 16pHQG;16 gene in delimiting the extent of the alpha-globin regulatory domain, we mapped its mouse orthologue, which we found to lie on mouse chromosome 17, separated from the mouse alpha-cluster on chromosome 11. Establishing the full extent of the human 16pHQG;16 gene has allowed us to define the centromeric limit of the region of conserved synteny around the human alpha-globin cluster to within an 8-kb segment of chromosome 16. |
| first_indexed | 2024-03-07T00:39:01Z |
| format | Journal article |
| id | oxford-uuid:8267c6a3-e609-4978-aacd-51ea712fe817 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:39:01Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | oxford-uuid:8267c6a3-e609-4978-aacd-51ea712fe8172022-03-26T21:37:07ZCharacterization of a widely expressed gene (LUC7-LIKE; LUC7L) defining the centromeric boundary of the human alpha-globin domain.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8267c6a3-e609-4978-aacd-51ea712fe817EnglishSymplectic Elements at Oxford2001Tufarelli, CFrischauf, AHardison, RFlint, JHiggs, DWe have identified the first gene lying on the centromeric side of the alpha-globin gene cluster on human 16p13.3. The gene, called 16pHQG;16 (HGMW-approved symbol LUC7L), is widely transcribed and lies in the opposite orientation with respect to the alpha-globin genes. This gene may represent a mammalian heterochromatic gene, encoding a putative RNA-binding protein similar to the yeast Luc7p subunit of the U1 snRNP splicing complex that is normally required for 5' splice site selection. To examine the role of the 16pHQG;16 gene in delimiting the extent of the alpha-globin regulatory domain, we mapped its mouse orthologue, which we found to lie on mouse chromosome 17, separated from the mouse alpha-cluster on chromosome 11. Establishing the full extent of the human 16pHQG;16 gene has allowed us to define the centromeric limit of the region of conserved synteny around the human alpha-globin cluster to within an 8-kb segment of chromosome 16. |
| spellingShingle | Tufarelli, C Frischauf, A Hardison, R Flint, J Higgs, D Characterization of a widely expressed gene (LUC7-LIKE; LUC7L) defining the centromeric boundary of the human alpha-globin domain. |
| title | Characterization of a widely expressed gene (LUC7-LIKE; LUC7L) defining the centromeric boundary of the human alpha-globin domain. |
| title_full | Characterization of a widely expressed gene (LUC7-LIKE; LUC7L) defining the centromeric boundary of the human alpha-globin domain. |
| title_fullStr | Characterization of a widely expressed gene (LUC7-LIKE; LUC7L) defining the centromeric boundary of the human alpha-globin domain. |
| title_full_unstemmed | Characterization of a widely expressed gene (LUC7-LIKE; LUC7L) defining the centromeric boundary of the human alpha-globin domain. |
| title_short | Characterization of a widely expressed gene (LUC7-LIKE; LUC7L) defining the centromeric boundary of the human alpha-globin domain. |
| title_sort | characterization of a widely expressed gene luc7 like luc7l defining the centromeric boundary of the human alpha globin domain |
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