A role for APP in Wnt signalling links synapse loss with β-amyloid production
In Alzheimer’s disease (AD), the canonical Wnt inhibitor Dickkopf-1 (Dkk1) is induced by β-amyloid (Aβ) and shifts the balance from canonical towards non-canonical Wnt signalling. Canonical (Wnt-β-catenin) signalling promotes synapse stability, while non-canonical (Wnt-PCP) signalling favours synaps...
| Hlavní autoři: | , , , , , , , , , , , , |
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| Médium: | Journal article |
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Springer Nature
2018
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