Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA.
Although cytotoxic T lymphocytes (CTLs) are thought to be involved in the control of human immunodeficiency virus-type 1 (HIV-1) infection, it has not been possible to demonstrate a direct relation between CTL activity and plasma RNA viral load. Human leukocyte antigen-peptide tetrameric complexes o...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
1998
|
| _version_ | 1797079006059692032 |
|---|---|
| author | Ogg, G Jin, X Bonhoeffer, S Dunbar, P Nowak, M Monard, S Segal, J Cao, Y Rowland-Jones, S Cerundolo, V Hurley, A Markowitz, M Ho, D Nixon, D Mcmichael, A |
| author_facet | Ogg, G Jin, X Bonhoeffer, S Dunbar, P Nowak, M Monard, S Segal, J Cao, Y Rowland-Jones, S Cerundolo, V Hurley, A Markowitz, M Ho, D Nixon, D Mcmichael, A |
| author_sort | Ogg, G |
| collection | OXFORD |
| description | Although cytotoxic T lymphocytes (CTLs) are thought to be involved in the control of human immunodeficiency virus-type 1 (HIV-1) infection, it has not been possible to demonstrate a direct relation between CTL activity and plasma RNA viral load. Human leukocyte antigen-peptide tetrameric complexes offer a specific means to directly quantitate circulating CTLs ex vivo. With the use of the tetrameric complexes, a significant inverse correlation was observed between HIV-specific CTL frequency and plasma RNA viral load. In contrast, no significant association was detected between the clearance rate of productively infected cells and frequency of HIV-specific CTLs. These data are consistent with a significant role for HIV-specific CTLs in the control of HIV infection and suggest a considerable cytopathic effect of the virus in vivo. |
| first_indexed | 2024-03-07T00:39:30Z |
| format | Journal article |
| id | oxford-uuid:828cd7f6-9b57-4fb3-9f5e-ae7c462feb4c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:39:30Z |
| publishDate | 1998 |
| record_format | dspace |
| spelling | oxford-uuid:828cd7f6-9b57-4fb3-9f5e-ae7c462feb4c2022-03-26T21:38:15ZQuantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:828cd7f6-9b57-4fb3-9f5e-ae7c462feb4cEnglishSymplectic Elements at Oxford1998Ogg, GJin, XBonhoeffer, SDunbar, PNowak, MMonard, SSegal, JCao, YRowland-Jones, SCerundolo, VHurley, AMarkowitz, MHo, DNixon, DMcmichael, AAlthough cytotoxic T lymphocytes (CTLs) are thought to be involved in the control of human immunodeficiency virus-type 1 (HIV-1) infection, it has not been possible to demonstrate a direct relation between CTL activity and plasma RNA viral load. Human leukocyte antigen-peptide tetrameric complexes offer a specific means to directly quantitate circulating CTLs ex vivo. With the use of the tetrameric complexes, a significant inverse correlation was observed between HIV-specific CTL frequency and plasma RNA viral load. In contrast, no significant association was detected between the clearance rate of productively infected cells and frequency of HIV-specific CTLs. These data are consistent with a significant role for HIV-specific CTLs in the control of HIV infection and suggest a considerable cytopathic effect of the virus in vivo. |
| spellingShingle | Ogg, G Jin, X Bonhoeffer, S Dunbar, P Nowak, M Monard, S Segal, J Cao, Y Rowland-Jones, S Cerundolo, V Hurley, A Markowitz, M Ho, D Nixon, D Mcmichael, A Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA. |
| title | Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA. |
| title_full | Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA. |
| title_fullStr | Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA. |
| title_full_unstemmed | Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA. |
| title_short | Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA. |
| title_sort | quantitation of hiv 1 specific cytotoxic t lymphocytes and plasma load of viral rna |
| work_keys_str_mv | AT oggg quantitationofhiv1specificcytotoxictlymphocytesandplasmaloadofviralrna AT jinx quantitationofhiv1specificcytotoxictlymphocytesandplasmaloadofviralrna AT bonhoeffers quantitationofhiv1specificcytotoxictlymphocytesandplasmaloadofviralrna AT dunbarp quantitationofhiv1specificcytotoxictlymphocytesandplasmaloadofviralrna AT nowakm quantitationofhiv1specificcytotoxictlymphocytesandplasmaloadofviralrna AT monards quantitationofhiv1specificcytotoxictlymphocytesandplasmaloadofviralrna AT segalj quantitationofhiv1specificcytotoxictlymphocytesandplasmaloadofviralrna AT caoy quantitationofhiv1specificcytotoxictlymphocytesandplasmaloadofviralrna AT rowlandjoness quantitationofhiv1specificcytotoxictlymphocytesandplasmaloadofviralrna AT cerundolov quantitationofhiv1specificcytotoxictlymphocytesandplasmaloadofviralrna AT hurleya quantitationofhiv1specificcytotoxictlymphocytesandplasmaloadofviralrna AT markowitzm quantitationofhiv1specificcytotoxictlymphocytesandplasmaloadofviralrna AT hod quantitationofhiv1specificcytotoxictlymphocytesandplasmaloadofviralrna AT nixond quantitationofhiv1specificcytotoxictlymphocytesandplasmaloadofviralrna AT mcmichaela quantitationofhiv1specificcytotoxictlymphocytesandplasmaloadofviralrna |