Exposure-response relationships in asthma caused by tetrachlorophthalic anhydride
Four patients with asthma caused by occupational exposure to tetrachlorophthalic anhydride (TCPA) had dust-challenge tests that used eight different levels ofTCPA exposure. Measurements ofTCPA in the test-cubicle air ranged from 1.3 to 961.1 fjig/m3. The higher exposures provoked definite late or du...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1990
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| Summary: | Four patients with asthma caused by occupational exposure to tetrachlorophthalic anhydride (TCPA) had dust-challenge tests that used eight different levels ofTCPA exposure. Measurements ofTCPA in the test-cubicle air ranged from 1.3 to 961.1 fjig/m3. The higher exposures provoked definite late or dual asthmatic responses. Smaller, but statistically significant, responses were observed at low exposures. The late asthmatic-response area had a linear relation to the logarithm of TCPA exposure, but the immediate asthmatic response was less closely related to exposure. |
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