3,3′-Disubstituted 5,5′-Bi(1,2,4-triazine) derivatives with potent in vitro and in vivo antimalarial activity

3,3′-Disubstituted 5,5′-Bi(1,2,4-triazine) derivatives with potent in vitro and in vivo antimalarial activity

A series of 3,3′-disubstituted 5,5′-bi(1,2,4-triazine) derivatives was synthesized and screened against the erythrocytic stage of Plasmodium falciparum 3D7 line. The most potent dimer, 6k, with an IC50 (50% inhibitory concentration) of 0.008 μM, had high in vitro potency against P. falciparum lines...

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Hlavní autoři: Xue, L, Shi, D-H, Harjani, JR, Huang, F, Beveridge, J, Dingjan, T, Ban, K, Diab, S, Duffy, S, Lucantoni, L, Fletcher, S, Chiu, FCK, Blundell, SA, Ellis, K, Ralph, SA, Wirjanata, G, Teguh, S, Noviyanti, R, Chavchich, M, Creek, DJ, Price, R, Marfurt, J, Charman, SA, Cuellar, M, Strasser, J, Dahlin, J, Walters, MA, Edstein, M, Avery, VM, Baell, JB
Médium: Journal article
Jazyk:English
Vydáno: American Chemical Society 2019

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