Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses.

Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses.

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The immune response to HIV-1 in patients who carry human histocompatibility leukocyte antigen (HLA)-B27 is characterized by an immunodominant response to an epitope in p24 gag (amino acids 263-272, KRWIILGLNK). Substitution of lysine (K) or glycine (G) for arginine (R) at HIV-1 gag residue 264 (R264...

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Bibliographische Detailangaben
Hauptverfasser:	Kelleher, A, Long, C, Holmes, E, Allen, R, Wilson, J, Conlon, C, Workman, C, Shaunak, S, Olson, K, Goulder, P, Brander, C, Ogg, G, Sullivan, J, Dyer, W, Jones, I, Mcmichael, A, Rowland-Jones, S, Phillips, R
Format:	Journal article
Sprache:	English
Veröffentlicht:	2001

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