Frailty and fracture, disability, and falls: a multiple country study from the global longitudinal study of osteoporosis in women.
OBJECTIVES: To test whether women aged 55 and older with increasing evidence of a frailty phenotype would have greater risk of fractures, disability, and recurrent falls than women who were not frail, across geographic areas (Australia, Europe, and North America) and age groups. DESIGN: Multinationa...
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2013
|
| _version_ | 1797079073459011584 |
|---|---|
| author | Tom, SE Adachi, J Anderson, F Boonen, S Chapurlat, R Compston, J Cooper, C Gehlbach, S Greenspan, S Hooven, F Nieves, J Pfeilschifter, J Roux, C Silverman, S Wyman, A LaCroix, A |
| author_facet | Tom, SE Adachi, J Anderson, F Boonen, S Chapurlat, R Compston, J Cooper, C Gehlbach, S Greenspan, S Hooven, F Nieves, J Pfeilschifter, J Roux, C Silverman, S Wyman, A LaCroix, A |
| author_sort | Tom, SE |
| collection | OXFORD |
| description | OBJECTIVES: To test whether women aged 55 and older with increasing evidence of a frailty phenotype would have greater risk of fractures, disability, and recurrent falls than women who were not frail, across geographic areas (Australia, Europe, and North America) and age groups. DESIGN: Multinational, longitudinal, observational cohort study. SETTING: Global Longitudinal Study of Osteoporosis in Women (GLOW). PARTICIPANTS: Women (N = 48,636) aged 55 and older enrolled at sites in Australia, Europe, and North America. MEASUREMENTS: Components of frailty (slowness and weakness, poor endurance and exhaustion, physical activity, and unintentional weight loss) at baseline and report of fracture, disability, and recurrent falls at 1 year of follow-up were investigated. Women also reported health and demographic characteristics at baseline. RESULTS: Women younger than 75 from the United States were more likely to be prefrail and frail than those from Australia, Canada, and Europe. The distribution of frailty was similar according to region for women aged 75 and older. Odds ratios from multivariable models for frailty versus nonfrailty were 1.23 (95% confidence interval (CI) = 1.07-1.42) for fracture, 2.29 (95% CI = 2.09-2.51) for disability, and 1.68 (95% CI = 1.54-1.83) for recurrent falls. The associations for prefrailty versus nonfrailty were weaker but still indicated statistically significantly greater risk of each outcome. Overall, associations between frailty and each outcome were similar across age and geographic region. CONCLUSION: Greater evidence of a frailty phenotype is associated with greater risk of fracture, disability, and falls in women aged 55 and older in 10 countries, with similar patterns across age and geographic region. |
| first_indexed | 2024-03-07T00:40:28Z |
| format | Journal article |
| id | oxford-uuid:82da9914-8280-4552-bfc9-cd65cbde058e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:40:28Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:82da9914-8280-4552-bfc9-cd65cbde058e2022-03-26T21:40:19ZFrailty and fracture, disability, and falls: a multiple country study from the global longitudinal study of osteoporosis in women.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:82da9914-8280-4552-bfc9-cd65cbde058eEnglishSymplectic Elements at Oxford2013Tom, SEAdachi, JAnderson, FBoonen, SChapurlat, RCompston, JCooper, CGehlbach, SGreenspan, SHooven, FNieves, JPfeilschifter, JRoux, CSilverman, SWyman, ALaCroix, AOBJECTIVES: To test whether women aged 55 and older with increasing evidence of a frailty phenotype would have greater risk of fractures, disability, and recurrent falls than women who were not frail, across geographic areas (Australia, Europe, and North America) and age groups. DESIGN: Multinational, longitudinal, observational cohort study. SETTING: Global Longitudinal Study of Osteoporosis in Women (GLOW). PARTICIPANTS: Women (N = 48,636) aged 55 and older enrolled at sites in Australia, Europe, and North America. MEASUREMENTS: Components of frailty (slowness and weakness, poor endurance and exhaustion, physical activity, and unintentional weight loss) at baseline and report of fracture, disability, and recurrent falls at 1 year of follow-up were investigated. Women also reported health and demographic characteristics at baseline. RESULTS: Women younger than 75 from the United States were more likely to be prefrail and frail than those from Australia, Canada, and Europe. The distribution of frailty was similar according to region for women aged 75 and older. Odds ratios from multivariable models for frailty versus nonfrailty were 1.23 (95% confidence interval (CI) = 1.07-1.42) for fracture, 2.29 (95% CI = 2.09-2.51) for disability, and 1.68 (95% CI = 1.54-1.83) for recurrent falls. The associations for prefrailty versus nonfrailty were weaker but still indicated statistically significantly greater risk of each outcome. Overall, associations between frailty and each outcome were similar across age and geographic region. CONCLUSION: Greater evidence of a frailty phenotype is associated with greater risk of fracture, disability, and falls in women aged 55 and older in 10 countries, with similar patterns across age and geographic region. |
| spellingShingle | Tom, SE Adachi, J Anderson, F Boonen, S Chapurlat, R Compston, J Cooper, C Gehlbach, S Greenspan, S Hooven, F Nieves, J Pfeilschifter, J Roux, C Silverman, S Wyman, A LaCroix, A Frailty and fracture, disability, and falls: a multiple country study from the global longitudinal study of osteoporosis in women. |
| title | Frailty and fracture, disability, and falls: a multiple country study from the global longitudinal study of osteoporosis in women. |
| title_full | Frailty and fracture, disability, and falls: a multiple country study from the global longitudinal study of osteoporosis in women. |
| title_fullStr | Frailty and fracture, disability, and falls: a multiple country study from the global longitudinal study of osteoporosis in women. |
| title_full_unstemmed | Frailty and fracture, disability, and falls: a multiple country study from the global longitudinal study of osteoporosis in women. |
| title_short | Frailty and fracture, disability, and falls: a multiple country study from the global longitudinal study of osteoporosis in women. |
| title_sort | frailty and fracture disability and falls a multiple country study from the global longitudinal study of osteoporosis in women |
| work_keys_str_mv | AT tomse frailtyandfracturedisabilityandfallsamultiplecountrystudyfromthegloballongitudinalstudyofosteoporosisinwomen AT adachij frailtyandfracturedisabilityandfallsamultiplecountrystudyfromthegloballongitudinalstudyofosteoporosisinwomen AT andersonf frailtyandfracturedisabilityandfallsamultiplecountrystudyfromthegloballongitudinalstudyofosteoporosisinwomen AT boonens frailtyandfracturedisabilityandfallsamultiplecountrystudyfromthegloballongitudinalstudyofosteoporosisinwomen AT chapurlatr frailtyandfracturedisabilityandfallsamultiplecountrystudyfromthegloballongitudinalstudyofosteoporosisinwomen AT compstonj frailtyandfracturedisabilityandfallsamultiplecountrystudyfromthegloballongitudinalstudyofosteoporosisinwomen AT cooperc frailtyandfracturedisabilityandfallsamultiplecountrystudyfromthegloballongitudinalstudyofosteoporosisinwomen AT gehlbachs frailtyandfracturedisabilityandfallsamultiplecountrystudyfromthegloballongitudinalstudyofosteoporosisinwomen AT greenspans frailtyandfracturedisabilityandfallsamultiplecountrystudyfromthegloballongitudinalstudyofosteoporosisinwomen AT hoovenf frailtyandfracturedisabilityandfallsamultiplecountrystudyfromthegloballongitudinalstudyofosteoporosisinwomen AT nievesj frailtyandfracturedisabilityandfallsamultiplecountrystudyfromthegloballongitudinalstudyofosteoporosisinwomen AT pfeilschifterj frailtyandfracturedisabilityandfallsamultiplecountrystudyfromthegloballongitudinalstudyofosteoporosisinwomen AT rouxc frailtyandfracturedisabilityandfallsamultiplecountrystudyfromthegloballongitudinalstudyofosteoporosisinwomen AT silvermans frailtyandfracturedisabilityandfallsamultiplecountrystudyfromthegloballongitudinalstudyofosteoporosisinwomen AT wymana frailtyandfracturedisabilityandfallsamultiplecountrystudyfromthegloballongitudinalstudyofosteoporosisinwomen AT lacroixa frailtyandfracturedisabilityandfallsamultiplecountrystudyfromthegloballongitudinalstudyofosteoporosisinwomen |