Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations.

Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations.

BACKGROUND: Heterozygous activating mutations in KCNJ11, encoding the Kir6.2 subunit of the ATP-sensitive potassium (K(ATP)) channel, cause 30 to 58 percent of cases of diabetes diagnosed in patients under six months of age. Patients present with ketoacidosis or severe hyperglycemia and are treated...

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Main Authors:	Pearson, E, Flechtner, I, Njølstad, P, Malecki, M, Flanagan, SE, Larkin, B, Ashcroft, F, Klimes, I, Codner, E, Iotova, V, Slingerland, A, Shield, J, Robert, J, Holst, J, Clark, P, Ellard, S, Søvik, O, Polak, M, Hattersley, A
Format:	Journal article
Language:	English
Published:	2006

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