T cell receptor usage of virus-specific CD8 cells and recognition of viral mutations during acute and persistent hepatitis B virus infection.
T cells specific for a single viral epitope, but using different T cell receptors, should have flexibility in their epitope recognition to protect the infected host against the emergence of viral escape mutants. Therefore, polyclonality of the hepatitis B virus (HBV)-specific cytotoxic T lymphocyte...
Huvudupphovsmän: | Maini, M, Reignat, S, Boni, C, Ogg, G, King, A, Malacarne, F, Webster, G, Bertoletti, A |
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Materialtyp: | Journal article |
Språk: | English |
Publicerad: |
2000
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