1.5 Fluorine in Medicinal Chemistry: Importance of Chirality
The number of compounds with fluorine or trifluoromethyl groups present on a stereogenic carbon in pharmaceutical targets on the market is small, especially when compared with pharmaceuticals containing fluorinated and trifluoromethylated aromatic rings. This is despite the beneficial physical prope...
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| 格式: | Book section |
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Elsevier
2012
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