Glucocorticosteroids as dengue therapeutics: resolving clinical observations with a primary human macrophage model.
A recent trial [1] investigated the use of a glucocorticosteroid, prednisolone, as a therapy for reduction of severe dengue disease. Many pathogens induce accelerated or excessive inflammation, resulting in detrimental rather than protective effects [2], and dengue virus is a well-characterized exam...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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Oxford University Press
2012
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| _version_ | 1797079100370714624 |
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| author | Sayce, A Miller, J Zitzmann, N |
| author_facet | Sayce, A Miller, J Zitzmann, N |
| author_sort | Sayce, A |
| collection | OXFORD |
| description | A recent trial [1] investigated the use of a glucocorticosteroid, prednisolone, as a therapy for reduction of severe dengue disease. Many pathogens induce accelerated or excessive inflammation, resulting in detrimental rather than protective effects [2], and dengue virus is a well-characterized example of this phenomenon. Several soluble mediators of the innate inflammatory response have been linked with severe pathology [3]; however, these studies are largely correlative and have failed to elucidate molecular mechanisms facilitating specific pathologies. Nevertheless, continued observation of excessive inflammation concurrent with a drop in viremia and development of severe symptoms [4, 5] has prompted several previous attempts at immunosuppressive strategies as a means of reducing severe dengue disease [6–9] |
| first_indexed | 2024-03-07T00:40:52Z |
| format | Journal article |
| id | oxford-uuid:82ff41b7-15d0-46a9-95f9-128d261587ad |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:40:52Z |
| publishDate | 2012 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:82ff41b7-15d0-46a9-95f9-128d261587ad2022-03-26T21:41:13ZGlucocorticosteroids as dengue therapeutics: resolving clinical observations with a primary human macrophage model.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:82ff41b7-15d0-46a9-95f9-128d261587adEnglishSymplectic Elements at OxfordOxford University Press2012Sayce, AMiller, JZitzmann, NA recent trial [1] investigated the use of a glucocorticosteroid, prednisolone, as a therapy for reduction of severe dengue disease. Many pathogens induce accelerated or excessive inflammation, resulting in detrimental rather than protective effects [2], and dengue virus is a well-characterized example of this phenomenon. Several soluble mediators of the innate inflammatory response have been linked with severe pathology [3]; however, these studies are largely correlative and have failed to elucidate molecular mechanisms facilitating specific pathologies. Nevertheless, continued observation of excessive inflammation concurrent with a drop in viremia and development of severe symptoms [4, 5] has prompted several previous attempts at immunosuppressive strategies as a means of reducing severe dengue disease [6–9] |
| spellingShingle | Sayce, A Miller, J Zitzmann, N Glucocorticosteroids as dengue therapeutics: resolving clinical observations with a primary human macrophage model. |
| title | Glucocorticosteroids as dengue therapeutics: resolving clinical observations with a primary human macrophage model. |
| title_full | Glucocorticosteroids as dengue therapeutics: resolving clinical observations with a primary human macrophage model. |
| title_fullStr | Glucocorticosteroids as dengue therapeutics: resolving clinical observations with a primary human macrophage model. |
| title_full_unstemmed | Glucocorticosteroids as dengue therapeutics: resolving clinical observations with a primary human macrophage model. |
| title_short | Glucocorticosteroids as dengue therapeutics: resolving clinical observations with a primary human macrophage model. |
| title_sort | glucocorticosteroids as dengue therapeutics resolving clinical observations with a primary human macrophage model |
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