Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain

Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain

Kv3 channels have distinctive gating kinetics tailored for rapid repolarization in fast-spiking neurons. Malfunction of this process due to genetic variants in the KCNC1 gene causes severe epileptic disorders, yet the structural determinants for the unusual gating properties remain elusive. Here, we...

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Dades bibliogràfiques
Autors principals:	Chi, G, Liang, Q, Sridhar, A, Cowgill, JB, Sader, K, Radjainia, M, Qian, P, Castro-Hartmann, P, Venkaya, S, Singh, NK, McKinley, G, Fernandez-Cid, A, Mukhopadhyay, SMM, Burgess-Brown, NA, Delemotte, L, Covarrubias, M, Dürr, KL
Format:	Journal article
Idioma:	English
Publicat:	Springer Nature 2022

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