CHK1 inhibition exacerbates replication stress induced by IGF blockade
We recently reported that genetic or pharmacological inhibition of insulin-like growth factor receptor (IGF-1R) slows DNA replication and induces replication stress by downregulating the regulatory subunit RRM2 of ribonucleotide reductase, perturbing deoxynucleotide triphosphate (dNTP) supply. Aimin...
Main Authors: | Wu, X, Seraia, E, Hatch, SB, Wan, X, Ebner, DV, Aroldi, F, Jiang, Y, Ryan, AJ, Bogenrieder, T, Weyer-Czernilofsky, U, Rieunier, G, Macaulay, VM |
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Format: | Journal article |
Language: | English |
Published: |
Springer Nature
2021
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