Glycosphingolipids in endocytic membrane transport.
Endocytosis leads to the internalisation of both lipids and proteins and their delivery to specific subcellular locations. This involves sorting processes that are not completely understood, but may involve interactions between lipids and proteins as well as pH and calcium gradients. This article di...
| Main Authors: | , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2004
|
| _version_ | 1797079152718774272 |
|---|---|
| author | Sillence, D Platt, F |
| author_facet | Sillence, D Platt, F |
| author_sort | Sillence, D |
| collection | OXFORD |
| description | Endocytosis leads to the internalisation of both lipids and proteins and their delivery to specific subcellular locations. This involves sorting processes that are not completely understood, but may involve interactions between lipids and proteins as well as pH and calcium gradients. This article discusses the importance of endocytosis in glycosphingolipid (GSL) synthesis as well as the potential roles of GSLs in endocytic membrane transport. Although the accumulation of GSLs in storage diseases clearly disrupts endocytic transport, increasing evidence also supports a role for GSLs in endocytosis in normal cells. |
| first_indexed | 2024-03-07T00:41:39Z |
| format | Journal article |
| id | oxford-uuid:833eab85-c8c8-45cf-9069-c50ede876faf |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:41:39Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:833eab85-c8c8-45cf-9069-c50ede876faf2022-03-26T21:42:55ZGlycosphingolipids in endocytic membrane transport.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:833eab85-c8c8-45cf-9069-c50ede876fafEnglishSymplectic Elements at Oxford2004Sillence, DPlatt, FEndocytosis leads to the internalisation of both lipids and proteins and their delivery to specific subcellular locations. This involves sorting processes that are not completely understood, but may involve interactions between lipids and proteins as well as pH and calcium gradients. This article discusses the importance of endocytosis in glycosphingolipid (GSL) synthesis as well as the potential roles of GSLs in endocytic membrane transport. Although the accumulation of GSLs in storage diseases clearly disrupts endocytic transport, increasing evidence also supports a role for GSLs in endocytosis in normal cells. |
| spellingShingle | Sillence, D Platt, F Glycosphingolipids in endocytic membrane transport. |
| title | Glycosphingolipids in endocytic membrane transport. |
| title_full | Glycosphingolipids in endocytic membrane transport. |
| title_fullStr | Glycosphingolipids in endocytic membrane transport. |
| title_full_unstemmed | Glycosphingolipids in endocytic membrane transport. |
| title_short | Glycosphingolipids in endocytic membrane transport. |
| title_sort | glycosphingolipids in endocytic membrane transport |
| work_keys_str_mv | AT sillenced glycosphingolipidsinendocyticmembranetransport AT plattf glycosphingolipidsinendocyticmembranetransport |