Brn-2 represses microphthalmia-associated transcription factor expression and marks a distinct subpopulation of microphthalmia-associated transcription factor-negative melanoma cells.
The origin of tumor heterogeneity is poorly understood, yet it represents a major barrier to effective therapy. In melanoma and in melanocyte development, the microphthalmia-associated transcription factor (Mitf) controls survival, differentiation, proliferation, and migration/metastasis. The Brn-2...
| Main Authors: | , , , , , , , , |
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| פורמט: | Journal article |
| שפה: | English |
| יצא לאור: |
2008
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| _version_ | 1826282300931833856 |
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| author | Goodall, J Carreira, S Denat, L Kobi, D Davidson, I Nuciforo, P Sturm, R Larue, L Goding, C |
| author_facet | Goodall, J Carreira, S Denat, L Kobi, D Davidson, I Nuciforo, P Sturm, R Larue, L Goding, C |
| author_sort | Goodall, J |
| collection | OXFORD |
| description | The origin of tumor heterogeneity is poorly understood, yet it represents a major barrier to effective therapy. In melanoma and in melanocyte development, the microphthalmia-associated transcription factor (Mitf) controls survival, differentiation, proliferation, and migration/metastasis. The Brn-2 (N-Oct-3, POU3F2) transcription factor also regulates melanoma proliferation and is up-regulated by BRAF and beta-catenin, two key melanoma-associated signaling molecules. Here, we show that Brn-2 also regulates invasiveness and directly represses Mitf expression. Remarkably, in melanoma biopsies, Mitf and Brn-2 each mark a distinct subpopulation of melanoma cells, providing a striking illustration of melanoma tumor heterogeneity with implications for melanoma therapy. |
| first_indexed | 2024-03-07T00:41:46Z |
| format | Journal article |
| id | oxford-uuid:834a0ac9-0686-4a0e-99d7-c81f4e30ffa8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:41:46Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:834a0ac9-0686-4a0e-99d7-c81f4e30ffa82022-03-26T21:43:13ZBrn-2 represses microphthalmia-associated transcription factor expression and marks a distinct subpopulation of microphthalmia-associated transcription factor-negative melanoma cells.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:834a0ac9-0686-4a0e-99d7-c81f4e30ffa8EnglishSymplectic Elements at Oxford2008Goodall, JCarreira, SDenat, LKobi, DDavidson, INuciforo, PSturm, RLarue, LGoding, CThe origin of tumor heterogeneity is poorly understood, yet it represents a major barrier to effective therapy. In melanoma and in melanocyte development, the microphthalmia-associated transcription factor (Mitf) controls survival, differentiation, proliferation, and migration/metastasis. The Brn-2 (N-Oct-3, POU3F2) transcription factor also regulates melanoma proliferation and is up-regulated by BRAF and beta-catenin, two key melanoma-associated signaling molecules. Here, we show that Brn-2 also regulates invasiveness and directly represses Mitf expression. Remarkably, in melanoma biopsies, Mitf and Brn-2 each mark a distinct subpopulation of melanoma cells, providing a striking illustration of melanoma tumor heterogeneity with implications for melanoma therapy. |
| spellingShingle | Goodall, J Carreira, S Denat, L Kobi, D Davidson, I Nuciforo, P Sturm, R Larue, L Goding, C Brn-2 represses microphthalmia-associated transcription factor expression and marks a distinct subpopulation of microphthalmia-associated transcription factor-negative melanoma cells. |
| title | Brn-2 represses microphthalmia-associated transcription factor expression and marks a distinct subpopulation of microphthalmia-associated transcription factor-negative melanoma cells. |
| title_full | Brn-2 represses microphthalmia-associated transcription factor expression and marks a distinct subpopulation of microphthalmia-associated transcription factor-negative melanoma cells. |
| title_fullStr | Brn-2 represses microphthalmia-associated transcription factor expression and marks a distinct subpopulation of microphthalmia-associated transcription factor-negative melanoma cells. |
| title_full_unstemmed | Brn-2 represses microphthalmia-associated transcription factor expression and marks a distinct subpopulation of microphthalmia-associated transcription factor-negative melanoma cells. |
| title_short | Brn-2 represses microphthalmia-associated transcription factor expression and marks a distinct subpopulation of microphthalmia-associated transcription factor-negative melanoma cells. |
| title_sort | brn 2 represses microphthalmia associated transcription factor expression and marks a distinct subpopulation of microphthalmia associated transcription factor negative melanoma cells |
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