Prediagnostic circulating concentrations of plasma insulin-like growth factor-I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition
Insulin-like growth factor-I (IGF-I) has cancer promoting activities. However, the hypothesis that circulating IGF-I concentration is related to risk of lymphoma overall or its subtypes has not been examined prospectively. IGF-I concentration was measured in pre-diagnostic plasma samples from a nest...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
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John Wiley & Sons Ltd
2016
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| _version_ | 1797079160361844736 |
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| author | Perez-Cornago, A Appleby, P Tipper, S Key, T Allen, N Nieters, A Vermeulen, R Roulland, S Casabonne, D Kaaks, R Fortner, R Boeing, H Trichopoulou, A La Vecchia, C Klinaki, E Hansen, L Tjønneland, A Bonnet, F Fagherazzi, G Boutron-Ruault, M Pala, V Masala, G Sacerdote, C Peeters, P Bueno-de-Mesquita, H Weiderpass, E Dorronsoro, M Quirós, J Barricarte, A Gavrila, D Agudo, A Borgquist, S Rosendahl, A Melin, B Wareham, N Khaw, K Gunter, M Riboli, E Vineis, P Travis, R |
| author_facet | Perez-Cornago, A Appleby, P Tipper, S Key, T Allen, N Nieters, A Vermeulen, R Roulland, S Casabonne, D Kaaks, R Fortner, R Boeing, H Trichopoulou, A La Vecchia, C Klinaki, E Hansen, L Tjønneland, A Bonnet, F Fagherazzi, G Boutron-Ruault, M Pala, V Masala, G Sacerdote, C Peeters, P Bueno-de-Mesquita, H Weiderpass, E Dorronsoro, M Quirós, J Barricarte, A Gavrila, D Agudo, A Borgquist, S Rosendahl, A Melin, B Wareham, N Khaw, K Gunter, M Riboli, E Vineis, P Travis, R |
| author_sort | Perez-Cornago, A |
| collection | OXFORD |
| description | Insulin-like growth factor-I (IGF-I) has cancer promoting activities. However, the hypothesis that circulating IGF-I concentration is related to risk of lymphoma overall or its subtypes has not been examined prospectively. IGF-I concentration was measured in pre-diagnostic plasma samples from a nested case-control study of 1072 cases of lymphoid malignancies and 1072 individually matched controls from the European Prospective Investigation into Cancer and Nutrition. Odds ratios (ORs) and confidence intervals (CIs) for lymphoma were calculated using conditional logistic regression. IGF-I concentration was not associated with overall lymphoma risk (multivariable-adjusted OR for highest versus lowest third = 0.77 [95% CI=0.57-1.03], Ptrend = 0.06). There was no statistical evidence of heterogeneity in this association with IGF-I by sex, age at blood collection, time between blood collection and diagnosis, age at diagnosis, or body mass index (Pheterogeneity for all ≥ 0.05). There were no associations between IGF-I concentration and risk for specific BCL subtypes, T-cell lymphoma or Hodgkin lymphoma, although number of cases were small. In this European population, IGF-I concentration was not associated with risk of overall lymphoma. This study provides the first prospective evidence on circulating IGF-I concentrations and risk of lymphoma. Further prospective data are required to examine associations of IGF-I concentrations with lymphoma subtypes. |
| first_indexed | 2024-03-07T00:41:46Z |
| format | Journal article |
| id | oxford-uuid:834a2e01-b76c-4478-ba9a-b2196c3e416e |
| institution | University of Oxford |
| last_indexed | 2024-03-07T00:41:46Z |
| publishDate | 2016 |
| publisher | John Wiley & Sons Ltd |
| record_format | dspace |
| spelling | oxford-uuid:834a2e01-b76c-4478-ba9a-b2196c3e416e2022-03-26T21:43:19ZPrediagnostic circulating concentrations of plasma insulin-like growth factor-I and risk of lymphoma in the European Prospective Investigation into Cancer and NutritionJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:834a2e01-b76c-4478-ba9a-b2196c3e416eSymplectic Elements at OxfordJohn Wiley & Sons Ltd2016Perez-Cornago, AAppleby, PTipper, SKey, TAllen, NNieters, AVermeulen, RRoulland, SCasabonne, DKaaks, RFortner, RBoeing, HTrichopoulou, ALa Vecchia, CKlinaki, EHansen, LTjønneland, ABonnet, FFagherazzi, GBoutron-Ruault, MPala, VMasala, GSacerdote, CPeeters, PBueno-de-Mesquita, HWeiderpass, EDorronsoro, MQuirós, JBarricarte, AGavrila, DAgudo, ABorgquist, SRosendahl, AMelin, BWareham, NKhaw, KGunter, MRiboli, EVineis, PTravis, RInsulin-like growth factor-I (IGF-I) has cancer promoting activities. However, the hypothesis that circulating IGF-I concentration is related to risk of lymphoma overall or its subtypes has not been examined prospectively. IGF-I concentration was measured in pre-diagnostic plasma samples from a nested case-control study of 1072 cases of lymphoid malignancies and 1072 individually matched controls from the European Prospective Investigation into Cancer and Nutrition. Odds ratios (ORs) and confidence intervals (CIs) for lymphoma were calculated using conditional logistic regression. IGF-I concentration was not associated with overall lymphoma risk (multivariable-adjusted OR for highest versus lowest third = 0.77 [95% CI=0.57-1.03], Ptrend = 0.06). There was no statistical evidence of heterogeneity in this association with IGF-I by sex, age at blood collection, time between blood collection and diagnosis, age at diagnosis, or body mass index (Pheterogeneity for all ≥ 0.05). There were no associations between IGF-I concentration and risk for specific BCL subtypes, T-cell lymphoma or Hodgkin lymphoma, although number of cases were small. In this European population, IGF-I concentration was not associated with risk of overall lymphoma. This study provides the first prospective evidence on circulating IGF-I concentrations and risk of lymphoma. Further prospective data are required to examine associations of IGF-I concentrations with lymphoma subtypes. |
| spellingShingle | Perez-Cornago, A Appleby, P Tipper, S Key, T Allen, N Nieters, A Vermeulen, R Roulland, S Casabonne, D Kaaks, R Fortner, R Boeing, H Trichopoulou, A La Vecchia, C Klinaki, E Hansen, L Tjønneland, A Bonnet, F Fagherazzi, G Boutron-Ruault, M Pala, V Masala, G Sacerdote, C Peeters, P Bueno-de-Mesquita, H Weiderpass, E Dorronsoro, M Quirós, J Barricarte, A Gavrila, D Agudo, A Borgquist, S Rosendahl, A Melin, B Wareham, N Khaw, K Gunter, M Riboli, E Vineis, P Travis, R Prediagnostic circulating concentrations of plasma insulin-like growth factor-I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition |
| title | Prediagnostic circulating concentrations of plasma insulin-like growth factor-I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition |
| title_full | Prediagnostic circulating concentrations of plasma insulin-like growth factor-I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition |
| title_fullStr | Prediagnostic circulating concentrations of plasma insulin-like growth factor-I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition |
| title_full_unstemmed | Prediagnostic circulating concentrations of plasma insulin-like growth factor-I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition |
| title_short | Prediagnostic circulating concentrations of plasma insulin-like growth factor-I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition |
| title_sort | prediagnostic circulating concentrations of plasma insulin like growth factor i and risk of lymphoma in the european prospective investigation into cancer and nutrition |
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