Dimerization of arginyl-tRNA synthetase by free heme drives its inactivation in plasmodium falciparum
Excess cellular heme is toxic, and malaria parasites regulate its levels during hemoglobin digestion. Aminoacyl-tRNA synthetases are ubiquitous enzymes, and of these, arginyl-tRNA synthetase (RRS) is unique as its enzymatic product of charged tRNA is required for protein synthesis and degradation. W...
| Hlavní autoři: | , , |
|---|---|
| Médium: | Journal article |
| Vydáno: |
Cell Press
2016
|