Dimerization of arginyl-tRNA synthetase by free heme drives its inactivation in plasmodium falciparum

Dimerization of arginyl-tRNA synthetase by free heme drives its inactivation in plasmodium falciparum

Excess cellular heme is toxic, and malaria parasites regulate its levels during hemoglobin digestion. Aminoacyl-tRNA synthetases are ubiquitous enzymes, and of these, arginyl-tRNA synthetase (RRS) is unique as its enzymatic product of charged tRNA is required for protein synthesis and degradation. W...

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Những tác giả chính:	Jain, V, Yogavel, M, Sharma, A
Định dạng:	Journal article
Được phát hành:	Cell Press 2016

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