A major susceptibility locus for leprosy in India maps to chromosome 10p13.
Leprosy, a chronic infectious disease caused by Mycobacterium leprae, is prevalent in India, where about half of the world's estimated 800,000 cases occur. A role for the genetics of the host in variable susceptibility to leprosy has been indicated by familial clustering, twin studies, complex...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2001
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| _version_ | 1797079235934814208 |
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| author | Siddiqui, MR Meisner, S Tosh, K Balakrishnan, K Ghei, S Fisher, S Golding, M Shanker Narayan, N Sitaraman, T Sengupta, U Pitchappan, R Hill, A |
| author_facet | Siddiqui, MR Meisner, S Tosh, K Balakrishnan, K Ghei, S Fisher, S Golding, M Shanker Narayan, N Sitaraman, T Sengupta, U Pitchappan, R Hill, A |
| author_sort | Siddiqui, MR |
| collection | OXFORD |
| description | Leprosy, a chronic infectious disease caused by Mycobacterium leprae, is prevalent in India, where about half of the world's estimated 800,000 cases occur. A role for the genetics of the host in variable susceptibility to leprosy has been indicated by familial clustering, twin studies, complex segregation analyses and human leukocyte antigen (HLA) association studies. We report here a genetic linkage scan of the genomes of 224 families from South India, containing 245 independent affected sibpairs with leprosy, mainly of the paucibacillary type. In a two-stage genome screen using 396 microsatellite markers, we found significant linkage (maximum lod score (MLS) = 4.09, P < 2x10-5) on chromosome 10p13 for a series of neighboring microsatellite markers, providing evidence for a major locus for this prevalent infectious disease. Thus, despite the polygenic nature of infectious disease susceptibility, some major, non-HLA-linked loci exist that may be mapped through obtainable numbers of affected sibling pairs. |
| first_indexed | 2024-03-07T00:42:53Z |
| format | Journal article |
| id | oxford-uuid:83a883bb-190a-4d0d-8ef9-816ce0a4da0a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:42:53Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | oxford-uuid:83a883bb-190a-4d0d-8ef9-816ce0a4da0a2022-03-26T21:45:43ZA major susceptibility locus for leprosy in India maps to chromosome 10p13.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:83a883bb-190a-4d0d-8ef9-816ce0a4da0aEnglishSymplectic Elements at Oxford2001Siddiqui, MRMeisner, STosh, KBalakrishnan, KGhei, SFisher, SGolding, MShanker Narayan, NSitaraman, TSengupta, UPitchappan, RHill, ALeprosy, a chronic infectious disease caused by Mycobacterium leprae, is prevalent in India, where about half of the world's estimated 800,000 cases occur. A role for the genetics of the host in variable susceptibility to leprosy has been indicated by familial clustering, twin studies, complex segregation analyses and human leukocyte antigen (HLA) association studies. We report here a genetic linkage scan of the genomes of 224 families from South India, containing 245 independent affected sibpairs with leprosy, mainly of the paucibacillary type. In a two-stage genome screen using 396 microsatellite markers, we found significant linkage (maximum lod score (MLS) = 4.09, P < 2x10-5) on chromosome 10p13 for a series of neighboring microsatellite markers, providing evidence for a major locus for this prevalent infectious disease. Thus, despite the polygenic nature of infectious disease susceptibility, some major, non-HLA-linked loci exist that may be mapped through obtainable numbers of affected sibling pairs. |
| spellingShingle | Siddiqui, MR Meisner, S Tosh, K Balakrishnan, K Ghei, S Fisher, S Golding, M Shanker Narayan, N Sitaraman, T Sengupta, U Pitchappan, R Hill, A A major susceptibility locus for leprosy in India maps to chromosome 10p13. |
| title | A major susceptibility locus for leprosy in India maps to chromosome 10p13. |
| title_full | A major susceptibility locus for leprosy in India maps to chromosome 10p13. |
| title_fullStr | A major susceptibility locus for leprosy in India maps to chromosome 10p13. |
| title_full_unstemmed | A major susceptibility locus for leprosy in India maps to chromosome 10p13. |
| title_short | A major susceptibility locus for leprosy in India maps to chromosome 10p13. |
| title_sort | major susceptibility locus for leprosy in india maps to chromosome 10p13 |
| work_keys_str_mv | AT siddiquimr amajorsusceptibilitylocusforleprosyinindiamapstochromosome10p13 AT meisners amajorsusceptibilitylocusforleprosyinindiamapstochromosome10p13 AT toshk amajorsusceptibilitylocusforleprosyinindiamapstochromosome10p13 AT balakrishnank amajorsusceptibilitylocusforleprosyinindiamapstochromosome10p13 AT gheis amajorsusceptibilitylocusforleprosyinindiamapstochromosome10p13 AT fishers amajorsusceptibilitylocusforleprosyinindiamapstochromosome10p13 AT goldingm amajorsusceptibilitylocusforleprosyinindiamapstochromosome10p13 AT shankernarayann amajorsusceptibilitylocusforleprosyinindiamapstochromosome10p13 AT sitaramant amajorsusceptibilitylocusforleprosyinindiamapstochromosome10p13 AT senguptau amajorsusceptibilitylocusforleprosyinindiamapstochromosome10p13 AT pitchappanr amajorsusceptibilitylocusforleprosyinindiamapstochromosome10p13 AT hilla amajorsusceptibilitylocusforleprosyinindiamapstochromosome10p13 AT siddiquimr majorsusceptibilitylocusforleprosyinindiamapstochromosome10p13 AT meisners majorsusceptibilitylocusforleprosyinindiamapstochromosome10p13 AT toshk majorsusceptibilitylocusforleprosyinindiamapstochromosome10p13 AT balakrishnank majorsusceptibilitylocusforleprosyinindiamapstochromosome10p13 AT gheis majorsusceptibilitylocusforleprosyinindiamapstochromosome10p13 AT fishers majorsusceptibilitylocusforleprosyinindiamapstochromosome10p13 AT goldingm majorsusceptibilitylocusforleprosyinindiamapstochromosome10p13 AT shankernarayann majorsusceptibilitylocusforleprosyinindiamapstochromosome10p13 AT sitaramant majorsusceptibilitylocusforleprosyinindiamapstochromosome10p13 AT senguptau majorsusceptibilitylocusforleprosyinindiamapstochromosome10p13 AT pitchappanr majorsusceptibilitylocusforleprosyinindiamapstochromosome10p13 AT hilla majorsusceptibilitylocusforleprosyinindiamapstochromosome10p13 |