Discovery and pharmacophoric characterization of chemokine network inhibitors using phage-display, saturation mutagenesis and computational modelling

Discovery and pharmacophoric characterization of chemokine network inhibitors using phage-display, saturation mutagenesis and computational modelling

CC and CXC-chemokines are the primary drivers of chemotaxis in inflammation, but chemokine network redundancy thwarts pharmacological intervention. Tick evasins promiscuously bind CC and CXC-chemokines, overcoming redundancy. Here we show that short peptides that promiscuously bind both chemokine cl...

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Bibliografiske detaljer
Main Authors:	Vales, S, Kryukova, J, Chandra, S, Smagurauskaite, G, Payne, M, Clark, CJ, Hafner, K, Mburu, P, Denisov, S, Davies, G, Outeiral, C, Deane, CM, Morris, GM, Bhattacharya, S
Format:	Journal article
Sprog:	English
Udgivet:	Springer Nature 2023

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