Discovery and pharmacophoric characterization of chemokine network inhibitors using phage-display, saturation mutagenesis and computational modelling

Discovery and pharmacophoric characterization of chemokine network inhibitors using phage-display, saturation mutagenesis and computational modelling

CC and CXC-chemokines are the primary drivers of chemotaxis in inflammation, but chemokine network redundancy thwarts pharmacological intervention. Tick evasins promiscuously bind CC and CXC-chemokines, overcoming redundancy. Here we show that short peptides that promiscuously bind both chemokine cl...

書誌詳細
主要な著者:	Vales, S, Kryukova, J, Chandra, S, Smagurauskaite, G, Payne, M, Clark, CJ, Hafner, K, Mburu, P, Denisov, S, Davies, G, Outeiral, C, Deane, CM, Morris, GM, Bhattacharya, S
フォーマット:	Journal article
言語:	English
出版事項:	Springer Nature 2023

類似資料

Discovery and pharmacophoric characterization of chemokine network inhibitors using phage-display, saturation mutagenesis and computational modelling
著者:: Serena Vales, 等
出版事項: (2023-09-01)

Deep generative design with 3D pharmacophoric constraints
著者:: Imrie, F, 等
出版事項: (2021)

Promoter analysis by saturation mutagenesis
著者:: Baliga Nitin
出版事項: (2001-01-01)

Pharmacophores and pharmacophore searches /
著者:: Langer, Thierry, 等
出版事項: (2006)

Hijacking Transposable Elements for Saturation Mutagenesis in Fungi
著者:: Sanne Schrevens, 等
出版事項: (2021-04-01)

Engineering Phage Host-Range and Suppressing Bacterial Resistance through Phage Tail Fiber Mutagenesis
著者:: Yehl, Kevin, 等
出版事項: (2021)

Current structure predictors are not learning the physics of protein folding
著者:: Outeiral, C, 等
出版事項: (2022)

Current structure predictors are not learning the physics of protein folding
著者:: Outeiral, C, 等
出版事項: (2022)

Impact of mutagenesis and lateral gene transfer processes in bacterial susceptibility to phage in food biocontrol and phage therapy
著者:: Júlia López-Pérez, 等
出版事項: (2023-09-01)

Deconstruction of the Ras switching cycle through saturation mutagenesis
著者:: Bandaru, Pradeep, 等
出版事項: (2018)

Deconstruction of the Ras switching cycle through saturation mutagenesis
著者:: Pradeep Bandaru, 等
出版事項: (2017-07-01)

Fitness loss and library size determination in saturation mutagenesis.
著者:: Yuval Nov
出版事項: (2013-01-01)

Investigating the potential for a limited quantum speedup on protein lattice problems
著者:: Outeiral, C, 等
出版事項: (2021)

Strategies for Bacteriophage T5 Mutagenesis: Expanding the Toolbox for Phage Genome Engineering
著者:: Luis Ramirez-Chamorro, 等
出版事項: (2021-04-01)

Identification of an alpha-1 antitrypsin variant with enhanced specificity for factor XIa by phage display, bacterial expression, and combinatorial mutagenesis
著者:: Varsha Bhakta, 等
出版事項: (2021-03-01)

A saturation-mutagenesis analysis of the interplay between stability and activation in Ras
著者:: Frank Hidalgo, 等
出版事項: (2022-03-01)

Computational and experimental methods for CRISPR-based saturation mutagenesis screens
著者:: Hsu, Jonathan Yee-Ting
出版事項: (2023)

Site Saturation Mutagenesis Applications on Candida methylica Formate Dehydrogenase
著者:: Gülşah P. Özgün, 等
出版事項: (2016-01-01)

Saturation Mutagenesis for Phenylalanine Ammonia Lyases of Enhanced Catalytic Properties
著者:: Raluca Bianca Tomoiagă, 等
出版事項: (2020-05-01)

The phage T4 DNA ligase in vivo improves the survival-coupled bacterial mutagenesis
著者:: Junshu Wang, 等
出版事項: (2019-06-01)

Site-directed mutagenesis of the CC chemokine binding protein 35K-Fc reveals residues essential for activity and mutations that increase the potency of CC chemokine blockade.
著者:: White, G, 等
出版事項: (2011)

Broad-spectrum chemokine-binding peptides from class A evasins
著者:: Vales, S
出版事項: (2024)

Enhancement of enzymatic properties of T1 lipase by saturation mutagenesis at glutamine 114 /
著者:: Roswanira Ab. Wahab, 等
出版事項: (2012)

Enhancement of enzymatic properties of T1 lipase by saturation mutagenesis at glutamine 114
著者:: Ab. Wahab, Roswanira
出版事項: (2012)

Improving the thermostability of alpha-amylase by combinatorial coevolving-site saturation mutagenesis
著者:: Wang Chenghua, 等
出版事項: (2012-10-01)

Saturation mutagenesis defines novel mouse models of severe spine deformity
著者:: Jonathan J. Rios, 等
出版事項: (2021-06-01)

Generation and site-directed mutagenesis of a 35K-Fc fusion protein with increased potency of CC chemokine blockade
著者:: White, G, 等
出版事項: (2010)

Exploring protein hotspots by optimized fragment pharmacophores
著者:: Bajusz, D, 等
出版事項: (2021)

Engineering allosteric inhibition of homoserine dehydrogenase by semi-rational saturation mutagenesis screening
著者:: Xinyang Liu, 等
出版事項: (2024-01-01)

Residue proximity information and protein model discrimination using saturation-suppressor mutagenesis
著者:: Anusmita Sahoo, 等
出版事項: (2015-12-01)

Prediction of Function Determining and Buried Residues Through Analysis of Saturation Mutagenesis Datasets
著者:: Munmun Bhasin, 等
出版事項: (2021-03-01)

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis
著者:: Canver, Matthew C., 等
出版事項: (2016)

Topological pharmacophores: pros & cons of QSARs based on 2D pharmacophore fingerprints
著者:: Horvath D
出版事項: (2008-03-01)

Ligand-Based Pharmacophore Modeling Using Novel 3D Pharmacophore Signatures
著者:: Alina Kutlushina, 等
出版事項: (2018-11-01)

Landscape Phage: Evolution from Phage Display to Nanobiotechnology
著者:: Valery A. Petrenko
出版事項: (2018-06-01)

Pharmacophore Models and Pharmacophore-Based Virtual Screening: Concepts and Applications Exemplified on Hydroxysteroid Dehydrogenases
著者:: Teresa Kaserer, 等
出版事項: (2015-12-01)

Quick and effective approximation of in silico saturation mutagenesis experiments with first-order taylor expansion
著者:: Alexander Sasse, 等
出版事項: (2024-09-01)

P1337: IDENTIFICATION OF CLONAL HEMATOPOIESIS DRIVER MUTATIONS THROUGH IN SILICO SATURATION MUTAGENESIS
著者:: Santiago Demajo, 等
出版事項: (2023-08-01)

Comprehensive essentiality analysis of the Mycobacterium kansasii genome by saturation transposon mutagenesis and deep sequencing
著者:: Keith Levendosky, 等
出版事項: (2023-08-01)

Data supporting a saturation mutagenesis assay for Tat-driven transcription with the GigaAssay
著者:: Ronald Benjamin, 等
出版事項: (2022-12-01)