Hypoxia. HIF-mediated articular chondrocyte function: prospects for cartilage repair.
In a chronically hypoxic tissue such as cartilage, adaptations to hypoxia do not merely include cell survival responses, but also promotion of its specific function. This review will focus on describing such hypoxia-mediated chondrocyte function, in particular in the permanent articular cartilage. T...
| Κύριοι συγγραφείς: | , , , |
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| Μορφή: | Journal article |
| Γλώσσα: | English |
| Έκδοση: |
2009
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| _version_ | 1826282395819573248 |
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| author | Murphy, C Thoms, B Vaghjiani, R Lafont, J |
| author_facet | Murphy, C Thoms, B Vaghjiani, R Lafont, J |
| author_sort | Murphy, C |
| collection | OXFORD |
| description | In a chronically hypoxic tissue such as cartilage, adaptations to hypoxia do not merely include cell survival responses, but also promotion of its specific function. This review will focus on describing such hypoxia-mediated chondrocyte function, in particular in the permanent articular cartilage. The molecular details of how chondrocytes sense and respond to hypoxia and how this promotes matrix synthesis have recently been examined, and specific manipulation of hypoxia-induced pathways is now considered to have potential therapeutic application to maintenance and repair of articular cartilage. |
| first_indexed | 2024-03-07T00:43:12Z |
| format | Journal article |
| id | oxford-uuid:83c48a8a-e7e0-4b75-a89b-12b06a5f29ef |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:43:12Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:83c48a8a-e7e0-4b75-a89b-12b06a5f29ef2022-03-26T21:46:24ZHypoxia. HIF-mediated articular chondrocyte function: prospects for cartilage repair.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:83c48a8a-e7e0-4b75-a89b-12b06a5f29efEnglishSymplectic Elements at Oxford2009Murphy, CThoms, BVaghjiani, RLafont, JIn a chronically hypoxic tissue such as cartilage, adaptations to hypoxia do not merely include cell survival responses, but also promotion of its specific function. This review will focus on describing such hypoxia-mediated chondrocyte function, in particular in the permanent articular cartilage. The molecular details of how chondrocytes sense and respond to hypoxia and how this promotes matrix synthesis have recently been examined, and specific manipulation of hypoxia-induced pathways is now considered to have potential therapeutic application to maintenance and repair of articular cartilage. |
| spellingShingle | Murphy, C Thoms, B Vaghjiani, R Lafont, J Hypoxia. HIF-mediated articular chondrocyte function: prospects for cartilage repair. |
| title | Hypoxia. HIF-mediated articular chondrocyte function: prospects for cartilage repair. |
| title_full | Hypoxia. HIF-mediated articular chondrocyte function: prospects for cartilage repair. |
| title_fullStr | Hypoxia. HIF-mediated articular chondrocyte function: prospects for cartilage repair. |
| title_full_unstemmed | Hypoxia. HIF-mediated articular chondrocyte function: prospects for cartilage repair. |
| title_short | Hypoxia. HIF-mediated articular chondrocyte function: prospects for cartilage repair. |
| title_sort | hypoxia hif mediated articular chondrocyte function prospects for cartilage repair |
| work_keys_str_mv | AT murphyc hypoxiahifmediatedarticularchondrocytefunctionprospectsforcartilagerepair AT thomsb hypoxiahifmediatedarticularchondrocytefunctionprospectsforcartilagerepair AT vaghjianir hypoxiahifmediatedarticularchondrocytefunctionprospectsforcartilagerepair AT lafontj hypoxiahifmediatedarticularchondrocytefunctionprospectsforcartilagerepair |