Evolution of acute hepatitis C virus infection in a large European city: Trends and new patterns
The aims of this study were to describe the evolution of acute hepatitis C virus (HCV) infections since 2004 and to determine its associated factors. Acute HCV infections diagnosed in Barcelona from 2004 to 2015 were included. Incidence ratios (IR) were then estimated for sex and age groups. Cases w...
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Published: |
Public Library of Science
2017
|
| _version_ | 1826282400814989312 |
|---|---|
| author | Garriga-Fuentes, C Manzanares-Laya, S Garcia de Olalla, P Gorrindo, P Lens, S Solà, R Martínez-Rebollar, M Laguno, M Navarro, J Torras, X Gurguí, M Barberá, M Quer, J Masdeu, E Simón, P Ros, M de Andrés, A Caylà, J |
| author_facet | Garriga-Fuentes, C Manzanares-Laya, S Garcia de Olalla, P Gorrindo, P Lens, S Solà, R Martínez-Rebollar, M Laguno, M Navarro, J Torras, X Gurguí, M Barberá, M Quer, J Masdeu, E Simón, P Ros, M de Andrés, A Caylà, J |
| author_sort | Garriga-Fuentes, C |
| collection | OXFORD |
| description | The aims of this study were to describe the evolution of acute hepatitis C virus (HCV) infections since 2004 and to determine its associated factors. Acute HCV infections diagnosed in Barcelona from 2004 to 2015 were included. Incidence ratios (IR) were then estimated for sex and age groups. Cases were grouped between 2004-2005, 2006-2011 and 2012-2015, and their incidence rate ratios (IRR) were calculated. In addition, risk factors for acute HCV infection were identified using multinomial logistic regression for complete, available and multiple imputed data. 204 new HCV cases were identified. Two peaks of higher IR of acute HCV infection in 2005 and 2013 were observed. Men and those aged 35 – 54 had higher IR. IRR for men was 2.9 times greater than in women (95% confidence intervals (CI): 1.8 ‒ 4.7). Factors related to the period 2012 – 2015 (versus 2006 – 2011) were: a) sexual risk factor for transmission versus nosocomial (relative-risk ratio (RRR): 13.0; 95% CI: 2.3 ‒ 72.1), b) higher educated versus lower (RRR: 5.4; 95% CI: 1.6 ‒ 18.7), and c) HIV co-infected versus not HIV-infected (RRR: 53.1; 95% CI: 5.7 ‒ 492.6). Conclusion: This is one of the few studies showing IR and RRRs of acute HCV infections and the first focused on a large city in Spain. Sexual risk for transmission between men, higher educational level and HIV co-infection are important factors for understanding current HCV epidemic. There has been a partial shift in the pattern of the risk factor for transmission from nosocomial to sexual. |
| first_indexed | 2024-03-07T00:43:17Z |
| format | Journal article |
| id | oxford-uuid:83c9cc5d-c3a4-4238-84b3-3098ae03fffe |
| institution | University of Oxford |
| last_indexed | 2024-03-07T00:43:17Z |
| publishDate | 2017 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | oxford-uuid:83c9cc5d-c3a4-4238-84b3-3098ae03fffe2022-03-26T21:46:38ZEvolution of acute hepatitis C virus infection in a large European city: Trends and new patternsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:83c9cc5d-c3a4-4238-84b3-3098ae03fffeSymplectic Elements at OxfordPublic Library of Science2017Garriga-Fuentes, CManzanares-Laya, SGarcia de Olalla, PGorrindo, PLens, SSolà, RMartínez-Rebollar, MLaguno, MNavarro, JTorras, XGurguí, MBarberá, MQuer, JMasdeu, ESimón, PRos, Mde Andrés, ACaylà, JThe aims of this study were to describe the evolution of acute hepatitis C virus (HCV) infections since 2004 and to determine its associated factors. Acute HCV infections diagnosed in Barcelona from 2004 to 2015 were included. Incidence ratios (IR) were then estimated for sex and age groups. Cases were grouped between 2004-2005, 2006-2011 and 2012-2015, and their incidence rate ratios (IRR) were calculated. In addition, risk factors for acute HCV infection were identified using multinomial logistic regression for complete, available and multiple imputed data. 204 new HCV cases were identified. Two peaks of higher IR of acute HCV infection in 2005 and 2013 were observed. Men and those aged 35 – 54 had higher IR. IRR for men was 2.9 times greater than in women (95% confidence intervals (CI): 1.8 ‒ 4.7). Factors related to the period 2012 – 2015 (versus 2006 – 2011) were: a) sexual risk factor for transmission versus nosocomial (relative-risk ratio (RRR): 13.0; 95% CI: 2.3 ‒ 72.1), b) higher educated versus lower (RRR: 5.4; 95% CI: 1.6 ‒ 18.7), and c) HIV co-infected versus not HIV-infected (RRR: 53.1; 95% CI: 5.7 ‒ 492.6). Conclusion: This is one of the few studies showing IR and RRRs of acute HCV infections and the first focused on a large city in Spain. Sexual risk for transmission between men, higher educational level and HIV co-infection are important factors for understanding current HCV epidemic. There has been a partial shift in the pattern of the risk factor for transmission from nosocomial to sexual. |
| spellingShingle | Garriga-Fuentes, C Manzanares-Laya, S Garcia de Olalla, P Gorrindo, P Lens, S Solà, R Martínez-Rebollar, M Laguno, M Navarro, J Torras, X Gurguí, M Barberá, M Quer, J Masdeu, E Simón, P Ros, M de Andrés, A Caylà, J Evolution of acute hepatitis C virus infection in a large European city: Trends and new patterns |
| title | Evolution of acute hepatitis C virus infection in a large European city: Trends and new patterns |
| title_full | Evolution of acute hepatitis C virus infection in a large European city: Trends and new patterns |
| title_fullStr | Evolution of acute hepatitis C virus infection in a large European city: Trends and new patterns |
| title_full_unstemmed | Evolution of acute hepatitis C virus infection in a large European city: Trends and new patterns |
| title_short | Evolution of acute hepatitis C virus infection in a large European city: Trends and new patterns |
| title_sort | evolution of acute hepatitis c virus infection in a large european city trends and new patterns |
| work_keys_str_mv | AT garrigafuentesc evolutionofacutehepatitiscvirusinfectioninalargeeuropeancitytrendsandnewpatterns AT manzanareslayas evolutionofacutehepatitiscvirusinfectioninalargeeuropeancitytrendsandnewpatterns AT garciadeolallap evolutionofacutehepatitiscvirusinfectioninalargeeuropeancitytrendsandnewpatterns AT gorrindop evolutionofacutehepatitiscvirusinfectioninalargeeuropeancitytrendsandnewpatterns AT lenss evolutionofacutehepatitiscvirusinfectioninalargeeuropeancitytrendsandnewpatterns AT solar evolutionofacutehepatitiscvirusinfectioninalargeeuropeancitytrendsandnewpatterns AT martinezrebollarm evolutionofacutehepatitiscvirusinfectioninalargeeuropeancitytrendsandnewpatterns AT lagunom evolutionofacutehepatitiscvirusinfectioninalargeeuropeancitytrendsandnewpatterns AT navarroj evolutionofacutehepatitiscvirusinfectioninalargeeuropeancitytrendsandnewpatterns AT torrasx evolutionofacutehepatitiscvirusinfectioninalargeeuropeancitytrendsandnewpatterns AT gurguim evolutionofacutehepatitiscvirusinfectioninalargeeuropeancitytrendsandnewpatterns AT barberam evolutionofacutehepatitiscvirusinfectioninalargeeuropeancitytrendsandnewpatterns AT querj evolutionofacutehepatitiscvirusinfectioninalargeeuropeancitytrendsandnewpatterns AT masdeue evolutionofacutehepatitiscvirusinfectioninalargeeuropeancitytrendsandnewpatterns AT simonp evolutionofacutehepatitiscvirusinfectioninalargeeuropeancitytrendsandnewpatterns AT rosm evolutionofacutehepatitiscvirusinfectioninalargeeuropeancitytrendsandnewpatterns AT deandresa evolutionofacutehepatitiscvirusinfectioninalargeeuropeancitytrendsandnewpatterns AT caylaj evolutionofacutehepatitiscvirusinfectioninalargeeuropeancitytrendsandnewpatterns |