The effect of clonidine and bright light on plasma melatonin
We studied the effect of α2-adrenoceptor agonist, clonidine, and bright artificial light (> 2500 lux) on the nocturnal increase in plasma melatonin in normal subjects. Clonidine (1.5 μg/kg, intravenously) was without effect on plasma melatonin concentration. In contrast, bright light treatmen...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1988
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| Summary: | We studied the effect of α2-adrenoceptor agonist, clonidine, and bright artificial light (> 2500 lux) on the nocturnal increase in plasma melatonin in normal subjects. Clonidine (1.5 μg/kg, intravenously) was without effect on plasma melatonin concentration. In contrast, bright light treatment abolished the increase in night-time melatonin. Bright light is a simple and effective means of altering melatonin secretion in humans. |
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